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Юридический и почтовый адрес учредителя и издателя: САФУ им. М.В. Ломоносова,  наб. Северной Двины, д. 17, г. Архангельск, Россия, 163002

Адрес редакции: «Журнал медико-биологических исследований», ул. Урицкого, 56, г. Архангельск

Тел: (8182) 21-61-00, вн. 18-20 
e-mail: vestnik_med@narfu.ru
Сайт: https://vestnikmed.ru

о журнале

Влияние различных типов физической нагрузки на функциональное состояние печени мышей при диабете 2-го типа (обзор). C. 73-89

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Рубрика: Научные обзоры

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УДК

[616.36+59.084]:[616.379-008.64+612.766.1]

DOI

10.37482/2687-1491-Z271

Сведения об авторах

Юйфэнь Юнь* ORCID: https://orcid.org/0009-0005-8495-207X
Елена Юрьевна Дьякова* ORCID: https://orcid.org/0000-0001-7653-2386
Сяньбо Цюй* ORCID: https://orcid.org/0000-0002-0237-7915

*Национальный исследовательский Томский государственный университет
(Томск, Россия)

Ответственный за переписку: Юйфэнь Юнь, адрес: 634050, г. Томск, просп. Ленина, д. 36; е-mail: q634920875@163.com

Аннотация

Сахарный диабет 2-го типа вызывает комплексные системные нарушения, при этом печень, будучи центральным органом углеводного и липидного обмена, является одной из основных мишеней хронических диабетических осложнений. Регулярная физическая активность рассматривается как эффективное немедикаментозное средство коррекции метаболических расстройств, связанных с указанным заболеванием. Цель настоящего обзора – сравнительный анализ влияния различных форм физической активности на показатели функционального состояния печени у животных с экспериментальной моделью сахарного диабета 2-го типа. Материалы и методы. Выполнен сетевой метаанализ, охватывающий 38 рандомизированных контролируемых исследований (суммарно – с участием 601 мыши). Данные были собраны из баз Web of Science, PubMed, Scopus, CNKI и EBSCO. Рассматривались следующие виды нагрузок: аэробные и силовые тренировки, плавание, высокоинтенсивные интервальные тренировки, тренировки средней интенсивности, а также спонтанная двигательная активность. В качестве исходных критериев оценки учитывались уровни аланинаминотрансферазы (ALT), аспартатаминотрансферазы (AST), триглицеридов, липопротеинов высокой (ЛПВП) и низкой (ЛПНП) плотности, а также активность фосфоенолпируваткарбоксикиназы (PEPCK). Результаты. Анализ выявил, что высокоинтенсивные интервальные тренировки оказывали наиболее выраженное воздействие на функциональное состояние печени мышей с сахарным диабетом 2-го типа, обеспечивая значительное снижение уровней ALT и триглицеридов при одновременном повышении концентрации ЛПВП. Силовые тренировки продемонстрировали преимущество в снижении уровней AST, ЛПНП и активности PEPCK. Плавание и тренировки средней интенсивности также положительно влияли на ряд биомаркеров, однако их эффект был менее выраженным. На основании полученных данных можно сделать вывод, что высокоинтенсивные интервальные тренировки и силовые тренировки могут быть более эффективными стратегиями для регуляции метаболизма печени у мышей с сахарным диабетом 2-го типа. Эти результаты подчеркивают потенциал физической активности как безопасного и доступного метода коррекции диабетических нарушений печени, действенность которого требует дальнейшего подтверждения в клинических исследованиях.

Ключевые слова

сахарный диабет 2-го типа, функциональное состояние печени, липидный обмен, силовые тренировки, высокоинтенсивные интервальные тренировки, сетевой метаанализ

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