UDC

612.4:615.357

Authors

Vereshchagina Evgeniya Viktorovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Tipisova Elena Vasilyevna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Abstract

During the test with Synacthen Depot we found increased levels of cortisol and decreased thyrotropin and lutropin levels in the blood after 60 minutes. After 1 day we recorded a decline in cortisol, thyrotropin, triiodothyronine and testosterone levels and an increase in lutropin and follitropin levels. After 4 days the content of lutropin, follitropin and testosterone corresponded to the basal levels, while the level of triiodothyronine was lower than the initial one. Estradiol level was increased during all periods of the test.

Keywords

North, test with Synacthen Depot, compensatory mechanisms, cortisol, pituitary-gonadal system, pituitary-thyroid system.

References

1. Barashkov V.A., Tedder Yu.R. Adaptivnye reaktsii organizma pri razlichnom statuse shchitovidnoy zhelezy [Adaptive Responses of the Body with Different Thyroid Status]. Arkhangelsk, 2004. 78 p.
2. Murray R.K., Granner D.K., Mayes P.A., Rodwell V.W. Harper’s Biochemistry. Norwalk, San Mateo, 1988. (Russ. ed.: Marri R., Grenner D., Meyes P., Roduell V. Biokhimiya cheloveka: in 2 vols. Vol. 2. Moscow, 2004. 414 p.).
3. Blagosklonnaya Ya.V., Shlyakhto E.V., Babenko A.Yu. Endokrinologiya [Endocrinology]. St. Petersburg, 2007. 400 p.
4. Dedov I.I., Mel’nichenko G.A., Fadeev V.V. Endokrinologiya [Endocrinology]. Moscow, 2007. 632 p.
5. Instruktsiya po primeneniyu preparata “Sinakten-depo” ot 17.12.1998 g. [Instructions for the Use of “Synacthen Depot” of 17.12.1998]. Basel, 1998.
6. Leykok D.F., Vays P.G. Osnovy endokrinologii [Fundamentals of Endocrinology]. Moscow, 2000. 504 p.
7. Malyshev V.V., Strizhkov V.S. Antistressornyy effekt prolaktina [Anti-Stress Effect of Prolactin]. Byulleten’ eksperimental’noy biologii i meditsiny, 1984, vol. 97, no. 1, pp. 31–34.
8. Panin L.E. Biokhimicheskie mekhanizmy stressa [Biochemical Mechanisms of Stress]. Novosibirsk, 1983. 231 p.
9. Predely fiziologicheskogo kolebaniya v perifericheskoy krovi metabolitov, gormonov, limfotsitov, tsitokinov i immunoglobulinov u zhiteley Arkhangel’skoy oblasti: inform. materialy [The Range of Physiological Variations of Metabolites, Hormones, Lymphocytes, Cytokines and Immunoglobulins in the Peripheral Blood of Arkhangelsk Region Residents: Information Materials]. Comp. and ed. by Dobrodeeva L.K. Arkhangelsk, 2005. 52 p.
10. Samsonova V.M., Babichev V.N. Shchitovidnaya zheleza i gonady: ikh vzaimosvyaz’ i vzaimodeystvie [Thyroid Gland and Gonads: Their Relationship and Interaction]. Fiziologiya cheloveka, 1990, vol. 16, no. 2, pp. 113–120.
11. Tipisova E.V. Reaktivnost’ i kompensatornye reaktsii endokrinnoy sistemy u muzhskogo naseleniya Evropeyskogo Severa [Reactivity and Compensatory Responses of the Endocrine System in Male Population of the European North]. Yekaterinburg, 2009. 201 p.
12. Tipisova E.V. Reaktivnost’ kory nadpochechnikov u zhiteley Evropeyskogo Severa v dinamike AKTG-testa v razlichnye svetovye periody goda [Adrenal Cortex Reactivity in the Population of the European North in ACTH-test Dynamics in Various Light Periods of the Year]. Vestnik Pomorskogo universiteta. Ser.: Fiziologicheskie i psikhologopedagogicheskie nauki, 2006, no. 2 (10), pp. 32–38.
13. Shatsova E.N. Funktsional›nye rezervy kory nadpochechnikov u zhiteley Evropeyskogo Severa SSSR – zdorovykh i bol›nykh diffuznym toksicheskim zobom [Functional Reserves of the Adrenal Cortex in the Population of the European North of the USSR – Healthy and with Grave’s Disease]. Fiziologiya cheloveka, 1990, no. 5, pp. 161–164.
14. Endokrinnaya sistema i obmen veshchestv u cheloveka na Severe [Human Endocrine System and Metabolism in the North]. Syktyvkar, 1992. 156 p.