UDC

618.4-092(470.11)

Authors

Sukhanov Sergey Genrikhovich, Institute of Physical Education, Sport and Health, Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russia)

Abstract

The study included 595 healthy females aged 18–40 years living in the Arkhangelsk Region and the Nenets Autonomous Area. Pituitary (adenohypophysis) and ovary hormones were examined by means of radioimmunoassay. Some adaptive and pathologic signs were revealed in the reproductive axis, including: clinical manifestations of secondary hypogonadotropic hypogonadism, restructuring of interhormonal relationships, and menstrual disorders.

Keywords

duration of residence in the north, neuroendocrine centres, statistical modelling.

References

1. Akmaev I.G., Grinevich V.V. Neyro-immunoendokrinologiya gipotalamusa [Neuro-Immuno-Endocrinology of Hypothalamus]. Moscow, 2003. 168 p.
2. Gubkina Z.D. Fizicheskoe, polovoe razvitie i funktsii endokrinnoy sistemy u zhitel’nits zapolyarnykh rayonov Arkhangel’skoy oblasti: avtoref. dis. … d-ra med. nauk [Physical and Sexual Development, and Functions of the Endocrine System in Residents of the Polar Areas of the Arkhangelsk Region: Dr. Med. Sci. Diss. Abs.]. Arkhangelsk, 2007. 48 p.
3. Dil’man V.M. Endokrinologicheskaya onkologiya [Endocrine Oncology]. Leningrad, 1983. 408 p.
4. Kishkun A. A. Biologicheskiy vozrast i starenie: vozmozhnosti opredeleniya i puti korrektsii [Biological Age and Ageing: Possible Ways of Determination and Correction]. Moscow, 2008. 976 p.
5. Moroz E.V., Bekker V.I. Vozrastnye osobennosti funktsional’noy aktivnosti gipofizarno-gonadnoy sistemy [Age-Related Features of Functional Activity of the Pituitary-Gonadal Axis]. Tezisy dokladov 2-go Vsesoyuznogo s”ezda endokrinologov [Outline Reports of the 2nd All-Union Congress for Endocrinologists]. 16–19 December 1980. Leningrad, 1980, pp. 329–330.
6. Nikitin A.I. Vrednye faktory sredy i reproduktivnaya sistema cheloveka (otvetstvennost’ pered budushchimi pokoleniyami) [Harmful Environmental Factors and Human Reproductive System (Responsibility to Future Generations)]. St. Petersburg, 2005. 216 p.
7. Sukhanov S.G., Gubkina Z.D., Smirnov A.V. Sposoby otsenki reproduktivnoy funktsii u zhenshchin na Evropeyskom Severe [Methods for Reproductive Function Evaluation in Women Living in the European North]. Nauchnye rekomendatsii – narodnomu khozyaystvu: seriya preprintov soobshcheniy [Scientific Recommendations – to the National Economy: Preprint Series of Reports]. Iss. 84. 1990. 24 p.
8. Sukhanov S.G., Gubkina Z.D. Faktornye modeli mezhgormonal’nykh vzaimootnosheniy v dinamike ovarial’nomenstrual’nogo tsikla u zhenshchin Kraynego Severa [Factor Models of Inter-Hormonal Relationships in the Dynamics of Ovarian-Menstrual Cycle in Women Living in the Far North]. Uskorenie sotsial’no-ekonomicheskogo razvitiya Urala [Acceleration of Socio-Economic Development of the Urals]. Part 2. Sverdlovsk, 1989. pp. 92–94.
9. Tkachenko N.M. O neyrogormonal’nom kontrole ovulyatsii [On the Neurohormonal Control of Ovulation]. Akusherstvo i ginekologiya, 1978, no. 3, pp. 1–5.
10. Khamad”yanov U.R., Laricheva I.P., Smirnova L.K. Soderzhanie prolaktina, follikulostimuliruyushchego, lyuteiniziruyushchego gormonov, estradiola i progesterona v syvorotke krovi u zhenshchin s normal’nym menstrual’nym tsiklom [The Content of Prolactin, Follicle-Stimulating and Luteinizing Hormones, Estradiol, and Progesterone in the Serum of Women with Normal Menstrual Cycle]. Problemy endokrinologii, 1980, vol. 26, no. 2, pp. 32–37.
11. Shchedrina Z.R., Fanchenko N.D., Kokolina V.F. Funktsional’noe sostoyanie reproduktivnoy sistemy zhenskogo organizma v period ee stanovleniya [Functional State of the Female Reproductive System During Its Formation]. Tez. dokladov 2-y Vsesoyuznoy konferentsii pediatrov-endokrinologov [Outline Reports on the 2nd All-Union Conference for Pediatricians-Endocrinologists]. 30–31 May 1988. Moscow, 1988, p. 157.
12. Bulun S.E., Adashi E.Y. The Physiology and Pathology of the Female Reproductive Axis. Williams Textbook of Endocrinology, 11th ed. Philadelphia, 2008, pp. 541–599.
13. Neuroendocrinology. An Integrated Approach. Ed. by Lovejov D. J. Wiley & Sons, Ltd, 2005. 409 p.
14. Reproductive Endocrinology. A Molecular Approach. Ed. by Chedrese P.J., Springer Science Business Media, 2009.
15. Sam S., Frohman L.A. Normal Physiology of Hypothalamic Pituitary Regulation. Endocrinology and Metabolism Clinics of North America, 2008, vol. 37, no. 1, pp. 1–22.
16. Vidal S., Horvath E., Kovacs K., Scheithauer B.W. Tumors of the Adenohypophysis. Endocrine Pathology: Differential Diagnosis and Molecular Advances. New Jersey, 2004, pp. 62–94.