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Еffеct of pregnant women Blood Serum on Adrenoreactivity of Rat Right Ventricle Myocardium Reduced by Beta-Blockers. Pp. 77–88.

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Authors

Tsirkin Viktor Ivanovich, Department of Human Physiology, Kazan State Medical University (Kazan, Russia)

Korotaeva Yuliya Vladimirovna, Natural Geography Faculty, Vyatka State Humanities University (Kirov, Russia)

Abstract

To study the properties of the endogenous sensitizer of beta-adrenoceptors (ESBAR), having human serum as its source, we carried out experiments on 10 strips of right ventricle myocardium of 10 rats at 37 oC and evaluated adrenalin influence on the amplitude of contractions caused by electrostimulation (20 V, 5 ms, 1 Hz).

Keywords

myocardium, adrenaline, adrenoblockers, blood serum.

References

  1. Samodelkina E.O., Tsirkin V.I., Khlybova S.V., Kostyaev A.A., Tarlavina M.G., Norina S.P. Al’faadrenomoduliruyushchaya aktivnost’ syvorotki krovi neberemennykh i beremennykh zhenshchin [Alpha- Adrenomodulatory Activity of Serum Blood of Nonpregnant and Pregnant Women]. Vestnik NGU. Ser.: Biologiya, klinicheskaya meditsina, 2010, vol. 8 (3), pp. 52–58.
  2. Kashin R.Yu., Demina N.L., Tsirkin V.I., Tarlovskaya E.I. Al’fa- i Beta-adreno-, M-kholinomoduliruyushchaya aktivnost’ syvorotki krovi pri arterial’noy gipertenzii [Alpha- and Beta-Adreno-, M-Cholinomodulating and Myocyte-Stimulating Serum Activity in Arterial Hypertension]. Kardiovaskulyarnaya terapiya i profilaktika, 2008, no. 2, pp. 16–22.
  3. Korotaeva K.N., Vyaznikov V.A., Tsirkin V.I., Kostyaev A.A. Vliyanie syvorotki krovi cheloveka na sokratimost’ i β-adrenoreaktivnost’ izolirovannogo miokarda cheloveka [Influence of the Human Blood Serum on Contractility and β-adrenoreactivity of the Isolated Human Myocardium]. Fiziologiya cheloveka, 2011, vol. 37 (3), pp. 83–91.
  4. Tsirkin V.I., Nozdrachev A.D., Trukhin A.N., Sizova E.N. Vliyanie endogennykh modulyatorov β-adrenoi M-kholinoreaktivnosti na variabel’nost’ serdechnogo ritma [Influence of Endogenic Modulators of ß-adreno and M-cholinreactivity on Cardiac Pace Variability]. Doklady akademii nauk, 2004, vol. 394 (4), pp. 562–565.
  5. Glants S. Mediko-biologicheskaya statistika [Biomedical Statistics]. Moscow, 1999, p. 459.
  6. Tsirkin V.I., Kononova T.N., Sizova E.N., Popova I.V., Vakhrusheva A.S. Izmenenie β-adrenoi M-kholimoduliruyushchey aktivnosti syvorotki krovi i mochi pri bronkhial’noy astme [Changes in the Β-adrenergic And M-cholinergic Modulating Activities of the Blood Serum and Urine in Bronchial Asthma]. Fiziologiya cheloveka, 2008, vol. 34 (3), pp. 137–140.
  7. Korotaeva K.N., Nozdrachev A.D., Tsirkin V.I. Vliyanie syvorotki neberemennykh zhenshchin i lizofosfatidilkholina na effektivnost’ aktivatsii M-kholinoretseptorov miokarda krysy [Influence of Nonpregnant Women Blood Serum and Lizophosphatidilholine on Efficiency of Activation of Rat Myocardium M-Cholinoreactivity]. Vestnik Sankt-Peterburgskogo universiteta. Ser. 3: Biologiya, 2011, iss. 3, pp. 57–65.
  8. Korotaeva Yu.V. Gistidin povyshaet effektivnost’ aktivatsii beta-adrenoretseptorov izolirovannogo miokarda pravogo zheludochka serdtsa krysy pri blokade atenololom ili obzidanom [Histidine Increases Beta-adrenergic Receptors Activation Efficiency in Isolated Myocardium of Right Ventricle of Rat Heart at Blockade by Atenolol or Obsidan]. Voprosy fundamental’noy i prikladnoy fiziologii v issledovaniyakh studentov vuzov: tez. dokl. IV Vseros. molodezh. nauch. konf. [Issues of Fundamental and Applied Physiology in Researches Conducted by University Students: Outline Reports of the 4th All-Russian Youth Sci. Conf.]. 2012, pp. 36–38.
  9. Lopatin Yu.M., Dronova E.P. Kliniko-farmakoekonomicheskie aspekty primeneniya β-adrenoblokatorov u bol’nykh ishemicheskoy bolezn’yu serdtsa, podvergnutykh koronarnomu shuntirovaniyu [Clinical-Pharmacoeconomical Aspects of ß-adrenoblockers Use in Patients with Ischemic Heart Disease Undergoing Coronary Artery Bypass Grafting]. Kardiologiya, 2010, vol. 50 (9), pp. 15–22.
  10. Penkina Yu.A., Nozdrachev A.D., Tsirkin V.I. Vliyanie syvorotki krovi cheloveka, gistidina, triptofana, tirozina, mildronata i LFKh na inotropnyy effekt adrenalina v opytakh s miokardom lyagushki i krysy [Influence of Human Blood Serum, Histidine, Tryptophane, Tyrosine, Mildronat and Lysophosphatydylcholine on Positive Inotropic Effect of Adrenaline in Experiences with Frog and Rat Myocardium]. Vestnik Sankt-Peterburgskogo universiteta. Ser. 3: Biologiya, 2008, iss. 1, pp. 56–68.
  11. Sizova E.N., Tsirkin V.I. Fiziologicheskaya kharakteristika endogennykh modulyatorov β-adreno- i M-kholinoreaktivnosti [Physiological Characteristics of Endogenous Modulators of b-adrenergic and M-cholinergic Reactivity]. Kirov, 2006, p. 183.
  12. Tsirkin V.I., Nozdrachev A.D., Sazanova M.L., Dvoryanskiy S.A. Fiziologicheskie svoystva miotsitov arteriy i veny pupoviny cheloveka i vliyanie na nikh syvorotki pupovinnoy krovi [Human Umbilical Artery and Vein Myocyte Physiological Properties and Umbilical Blood Serum Influence on Them]. Doklady akademii nauk, 2003, vol. 388 (3), pp. 426–429.
  13. Tsirkin V. I., Nozdrachev A. D., Toropov A. L. Endogennyy sensibilizator beta-adrenoretseptorov i ego analogi v opytakh s miometriem krysy umen’shayut beta-adrenoblokiruyushchiy effekt obzidana [An Endogenous Sensitizer of β-adrenergic Receptors and Its Analogs in the Experiments with Rat Myometrium Reduce the β-adrenoblocking Effect of Obzidan]. Doklady akademii nauk, 2010, vol. 435 (1), pp. 131–137.
  14. Gauthier C., Rozec B., Manoury B., Balligand J. Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies. Curr. Heart Fail. Rep., 2011, vol. 8 (3), pp. 184–192.
  15. Bundkirchen A., Brixius K., Bölck B., Schwinger R. Bucindolol Exerts Agonistic Activity on the Propranolol- Insensitive State of Beta1-Adrenoceptors in Human Myocardium. J. Pharmacol. Exp. Ther., 2002, vol. 300 (3), pp. 794–801.
  16. Niu X., Watts V., Cingolani O., et al. Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism: Role of Neuronal Nitric Oxide Synthase. J. Am. Cell. Cardiol., 2012, vol. 59 (22), pp. 1979–1987.
  17. Buxton B., Jones S., Molenaar P., Summers R. Characterization and Autoradiographic Localization of Betaadrenoceptor Subtypes in Human Cardiac Tissues. Br. J. Pharmacol., 1987, vol. 92 (2), pp. 299–310.
  18. Sezai A., Nakai T., Hata M., et al. Feasibility of Landiolol and Bisoprolol for Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting: A Pilot Study. J. Thorac. Cardiovasc. Surg., 2012, vol. 144 (5), pp. 1241–1248.
  19. El-Ayoubi R., Menaouar A., Gutkowska J., Mukaddam-Daher S. Imidazoline Receptors but not Alpha 2-adrenoceptors Are Regulated in Spontaneously Hypertensive Rat Heart by Chronic Moxonidine Treatment. J. Pharmacol. Exp. Ther., 2004, vol. 310 (2), pp. 446–451.
  20. Chu C., Thai K., Park K., Wang P., Makwana O., Lovett D., Simpson P., Baker A. Intraventricular and Interventricular Cellular Heterogeneity of Inotropic Responses to α1-adrenergic Stimulation. Am. J. Physiol. Heart Circ. Physiol., 2013, vol. 304 (7), pp. 946–953.
  21. Lefkowitz R. Historical Review: A Brief History and Personal Retrospective of Seven-Transmembrane Receptors. Trends Pharmacol. Sci., 2004, vol. 25 (8), pp. 413–422.
  22. Pérez-Schindler J., Philp A., Hernandez-Cascales J. Pathophysiological Relevance of the Cardiac Β2-adrenergic Receptor and Its Potential as a Therapeutic Target to Improve Cardiac Function. Eur. J. Pharmacol., 2013, vol. 698 (1–3), pp. 39–47.
  23. Indolfi C., Piscione F., Villari B., et al. Role of Alpha 2-adrenoceptors in Normal and Atherosclerotic Human Coronary Circulation. Circulation, 1992, vol. 86 (4), pp. 1116–1124.



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