UDC

577.175.44:612.8

DOI

10.37482/2687-1491-Z254

Authors

Valentina N. Zyabisheva* ORCID: https://orcid.org/0000-0001-6133-8249
*N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Abstract

Personalized study of adaptive endocrine mechanisms related to the regulation of thyroid and adrenal gland functions in the context of the North remains one of the most significant issues in physiological research. With this in mind, the purpose of the article was to investigate the typological responses of peripheral dopamine during the period of minimum daylight hours and the corresponding changes in the levels of thyroid hormones, cortisol and autoantibodies to thyroid tissue in young women living in the European North of Russia. Materials and мethods. The research was conducted during the periods of decreasing and minimum daylight hours (September and December 2022) and involved 20 apparently healthy euthyroid women aged 24–42 years permanently living in Arkhangelsk. The levels of serum thyroid hormones, cortisol and thyroid autoantibodies as well as plasma dopamine were measured using enzyme immunoassay on an automated Elisys Uno (Human GmbH, Germany) analyser. Depending on the changes in dopamine concentrations during the period of minimum daylight hours compared to the previous photoperiod, the total sample was divided into two groups: those with increasing and those with decreasing (or unchanged) dopamine level. In addition, indices of peripheral conversion (T3/T4) and progressive peripheral conversion (FТ4/FТ3) of iodothyronines were calculated, demonstrating the functional state of the thyroid gland. Results. The decrease in dopamine secretion was accompanied by an increase in cortisol, triiodothyronine and thyroid peroxidase antibodies. The rise in dopamine concentration was accompanied by a decrease in cortisol and thyroglobulin antibodies. In both cases, peripheral conversion of total iodothyronine fractions intensified. The authors suggest that opposite changes in dopamine and cortisol levels during the transition to the period of minimum daylight hours may be related to the women’s level of adaptation to adverse climatic conditions. These changes may be a compensatory mechanism aimed at increasing the conversion of thyroxine to triiodothyronine, the most metabolically active hormone, during the winter in the European North of Russia.

Keywords

healthy women of the European North, typological photoperiodic reactions, pituitary-thyroid axis, peripheral dopamine, cortisol, thyroid gland, thyroid hormones, adaptation to northern climate

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