UDC

611.018.1:612.017.1(98)

Authors

Shchegoleva Lyubov Stanislavovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia) 

Abstract

Cytotoxic T-lymphocytes (CD8+, CD16+) determine cell-mediated cytotoxic activity in physiological responses of immune homeostasis in the north of the European part of Russia. In people under 40 years, the content of cytotoxic T-lymphocytes is higher than that in the older age group and is associated with the differentiation of T-cells, lymphoproliferation, and apoptosis. We found that increased content of CD8+ and CD16+ T-cells is required to maintain immune homeostasis and is associated with deficient phagocytic activity of mature and functionally active CD3+ cells, with increased levels of CD10+ lymphoproliferation and CD95+ apoptosis accompanied by lower activity of immune cells differentiation and higher cell-mediated cytotoxicity. Northerners aged 19–40 years often show increased values of lymphoproliferation (SD10+), natural killer cells (CD16+), and suppressor cells (CD8+). We revealed deficiency of T-cells and transferrin receptor cells (CD71+). The subjects from the older age group (41– 60 years) frequently had low concentrations of CD8+ and CD16+ (especially women) associated with increased activity of B-cell level (HLA-DR+), increased concentrations of CD71+, and a low level of apoptosis (CD95+). In northerners, the content of CD8+ and CD16+ T-cells in the peripheral blood, as well as the frequency of their recorded high levels are reducing with age; p < 0.01. Lymphoid subpopulations of CD8+ suppressors and CD16+ natural killer cells have a compensatory and protective role. The obtained data on the physiological importance of the content of cytotoxic lymphocytes (CD8+, CD16+) in the peripheral blood of northerners complement current views on the physiological mechanisms in people living in the north of the European part of Russia.

Keywords

cytotoxic T-lymphocytes, helper T-cells, natural killer cells, developmental immunology.

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