UDC

612.015.348:612.433.018

Authors

Bichkaeva Fatima Artemovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Technologies, Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russia) 

Abstract

The paper identified the rates of protein metabolism, biogenic amines, catecholamines, cortisol and insulin in adult population of the Circumpolar region (CR) in the Arkhangelsk Region and of South Caucasus (SC) in the Republic of South Ossetia aged 20 to 65 years. Residents of SC had a significant decrease of creatinine, urea and uric acid in the blood, accompanied by the activation of the sympathoadrenal system and insular apparatus of pancreas. The residents of CR had a significant increase in metabolites of protein metabolism with activation of the adrenal cortex and a decrease in insulin levels in the blood. In both regions, the incidence of adrenaline exceeding standard physiological concentrations was higher than that of noradrenaline: 55 and 64 % for adrenaline and 5 and 6 % for noradrenaline in CR and SC respectively. The correlation and regression analyses confirmed that the total protein level in the blood of people from CR depends on catecholamines (adrenaline, noradrenaline) and biogenic amines (serotonin, histamine) as well as that the content of its metabolites depends on the level of histamine and adrenaline. At the same time, in SC residents the levels of total protein and urea depend on the serotonin content, though mediated by uric acid. Besides, the greatest contribution to the changes in protein metabolism of CR residents was made by noradrenaline, histamine, and cortisol, either alone or in combination with such factors as sex, age, and, least of all, body mass index (65–92 %). In SC residents these were insulin, catecholamines, and biogenic amines, either alone or in combination with such factors as body mass index, age, and, least of all, sex (73–99 %). The results of this study can be used to detect metabolic syndrome at an early stage, taking into account regional peculiarities.

Keywords

protein metabolism, catecholamines, biogenic amines, insulin, cortisol, circumpolar region, Arkhangelsk Region, South Caucasus, South Ossetia.

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