UDC

612.133:575.113

Authors

Khromova Anna Vladimirovna, Northern State Medical University (Arkhangelsk, Russia) 

Abstract

The paper studied the incidence of -786T>C polymorphism of endothelial nitric oxide synthase (NOS3) gene among healthy young men aged 18–22 permanently living in the European North of Russia. It was revealed that the rarest polymorphic allele is CC. This variant was found in 11.2 % of the subjects, which is consistent with global data. In young men with normotensive response of the cardiovascular system to exercise, we found no statistically significant difference in the production of endothelium-derived vasoactive factors depending on -786T>C polymorphism in NOS3 gene. The worst polymorphic allele in terms of forming peripheral vasoconstriction in response to exercise is CC. Among the subjects with CC genotype, 57.9 % had hypertensive response to graduated exercise. The background index of peripheral vascular resistance at rest did not differ significantly among the subjects with hypertensive response regardless of the genotype and were normal. Among all the subjects with hypertensive response, the maximum peripheral resistance index after exercise was also found in CC genotype carriers. However, there was no statistically significant difference in the production of nitric oxide (NO) vasodilator depending on the genotype; while the lowest NO level was observed in the subjects with CC genotype. At the same time, the level of endothelin-1 (ET-1) and NO/ET-1 index in the subjects with CC genotype were statistically significantly different from those in CT and TT genotype carriers. Thus, the young men with CC genotype had a shift of balance in the production of endotheliumderived vasoactive factors towards vasoconstriction mainly due to increased production of ET-1. In general, the results allow us to consider the homozygous CC variant of -786T>C polymorphism in NOS3 gene as a predictor of endothelial dysfunction, peripheral vasoconstriction and arterial hypertension.

Keywords

-786T>C polymorphism of NOS3 gene, endothelin-1, nitric oxide, peripheral resistance index.

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