UDC

[616-008.9:612.799.1](571-1)

Authors

Korchina Tatyana Yakovlevna, Khanty-Mansiysk State Medical Academy (Khanty-Mansiysk, Russia) 

Abstract

This paper studied the elemental status of adult nonindigenous population living in the north-west of Russia: 72 patients with metabolic syndrome and 54 without metabolic syndrome. The patients’ hair was analysed for 25 chemical elements using inductively coupled plasma atomic emission spectrometry and mass spectrometry (ICP-AES and ICP-MS). Patients with metabolic syndrome showed a significant excess of the concentration of Cd (p = 0.028) and Na (p = 0.049) in the hair, together with a pronounced deficiency of Cr (p = 0.009), Mg (p = 0.006), Se (p < 0.001) and Zn (p = 0.007), compared to the control group. We found that Cr, Mg and Zn are actively involved in the regulation of carbohydrate and lipid metabolism. Along with the powerful antioxidant Se, Cr and Zn are part of antioxidant enzymes (zincand chromium-dependent superoxide dismutases); the toxic trace element Cd is taking part in blocking SH-groups of proteins and displacing Zn and other bioelements from their compounds, while excessive accumulation of Na contributes to water imbalance and fluid retention in the body. Thus, mineral and trace element metabolism in the human body can be one of the triggers of pathological disorders and diseases, including metabolic syndrome. That is why the evaluation of the elemental status of the body can tell us about the effectiveness of its physiological systems and the risk of developing diseases and can be used in prenosological diagnostics. Moreover, timely treatment of trace element and mineral metabolism disorders can be one of the methods of pathogenetic treatment and prevention of both metabolic syndrome and related disorders: dyslipidemia, type II diabetes, hypertension, and others.

Keywords

elemental status, elemental composition of hair, metabolic syndrome, northern region.

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