UDC

612.172

Authors

Tsirkin Viktor Ivanovich
Kazan State Medical University (Kazan, Russia)
Korotaeva Yuliya Vladimirovna
Postgraduate Student, Natural Geography Faculty, Vyatka State Humanities University (Kirov, Russia)

Abstract

Experiments were carried out on myocardium strips of right ventricular of 30 nonpregnant rats (15 were in proestrus or estrus, i.e. under the dominance of estrogens, and 15 – in metestrus or diestrus, i.e. under the dominance of progesterone). At the same time, we could not reveal any dependence of rat myocardium contractility on the phases of estrous cycle. Histidine, tryptophan and tyrosine (10-4 – –10-10 g/ml) do not increase the amplitude of myocardium contractions, i.e. these amino acids do not show the positive inotropic effect identified earlier. Histidine, tryptophan and tyrosine (10-10 –10-4 g/ml) do not enhance the ability of adrenaline (10- 9 g/ml) to have a positive inotropic effect, i.e. they are not involved in beta-adrenosensibilizing activity which is usually observed in experiments with rat myometrium. This can be explained by the fact that histidine, tryptophan and tyrosine, while increasing the activation efficiency of beta1- and beta2-adrenoreceptors, also increase it in beta3-adrenoreceptors, which, as is known, results in reduced myocardial contractility. We come to the conclusion that selective beta-adrenoreceptors sensitizers are a necessity having good prospects.

Keywords

histidine, tryptophan, tyrosine, myocardium contractility, beta-adrenoreceptors

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