UDC

576.32/.33:612.014:612.017.1

Authors

Filippova Oksana Evgenyevna
The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)
Dobrodeeva Liliya Konstantinovna
The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)
Shchegoleva Lyubov Stanislavovna
The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)
Shashkova Elizaveta Yuryevna
The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Abstract

We studied the ratio of lymphocyte phenotypes in healthy adult subjects aged 20–50 years under various climatic, environmental and working conditions: those living in the Arctic region (Nes village), both nomadic and settled ones; residents of Arkhangelsk working as hydrographers (shift work); lighthouse keepers; and Moscow dwellers (with no account taken of their occupations). It is shown that the physiological effect of immune response in humans depends not only on the number of active cells but also on their ratio. Workloads, lifestyle, and adverse environmental impact on the human body are aggravated by northern conditions as compared to the climatic conditions of central Russia and Moscow city. We found that the ratios of certain phenotypes of peripheral blood immune cells in the human body become apparent when choosing their lineage. It is at this stage that, under the influence of various factors (polar and circumpolar regions, occupation, metropolis, central Russia) and the differences in their temporal influence, the ratio of certain cell phenotypes becomes decisive and either stimulates or inhibits a specific stage in the development of immune response. This ratio also shows that differentiation of immune cells is significantly reduced in the north. Low activity of immune cells is associated with less effective protection and therapy. Immune responses at inflammations are rather stereotyped and include lymphocyte proliferation, increase in activated lymphocytes (CD25+, CD71+, HLA-DR+), as well as NKCD16, T-helper cells (CD4+) and Cytotoxic T cells (CD8+). The intensity of these reactions depends on the content of proinflammatory cytokines in the blood.

Keywords

activator cells, metropolis, hydrography, Arctic, immunity, nomads

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