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Analytical Survey of Endogenous Modulators of M-Cholinergic Receptors as Components of the Humoral Arm of the Autonomic Nervous System (Part 1). P. 37–50

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Section: Physiology

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Authors

Andrey N. Trukhin
Vyatka State Humanities University
26 Krasnoarmeyskaya St., Kirov, 610002, Russian Federation;
е-mail: trukhinandrey@rambler.ru
Aleksey A. Kunshin
Vyatka State Humanities University
26 Krasnoarmeyskaya St., Kirov, 610002, Russian Federation;
е-mail: tabyss@bk.ru

Abstract

This paper summarizes the available data in scientific literature (mainly obtained in the Laboratory of Muscle and Bioactive Substance Physiology, Vyatka State Humanities University) indicating the presence in human urine and serum of the endogenous blocker and endogenous sensitizer of M-cholinergic receptors (EBMChR and ESMChR) affecting in vitro the activation efficiency of M-cholinergic receptors (MChR) of uterine smooth muscles, blood vessels, trachea, and myocardium. Part 1 of the survey focuses on the history of the discovery of M-cholinolytic activity of animal blood serum and the emergence of the term EBMChR, as well as EBMChR phenomenology exhibited through experiments with longitudinal stripes of nonpregnant rat uterine horns, It is indicated that the manifestation of blood serum EBMChR activity depends on its dilution factor (it is best detected at 1:10, 1:50 and 1:100 dilutions), while the relative content of EBMChR in human blood depends on the age (being higher at the initial stages of ontogenesis) and presence of somatic diseases (being increased at coronary heart disease and, in some patients, at bronchial asthma, but reduced at stage 3 hypertension). EBMChR content does not depend on sex and in women on the stage of their reproductive process or such obstetric complications as uterine inertia, threatened premature delivery, and pre-eclampsia. Scientists have been searching for EBMChR analogs, lysophosphatidylcholine being especially noteworthy, and suggest considering it as EBMChR component. On the basis of the facts presented in both parts of our survey, we make a conclusion that EBMChR plays an important role in а healthy human and animal body, while its deficiency or excess can be directly linked to the formation of a number of somatic diseases. It is clear that, together with other components of the humoral arm of the autonomic nervous system, EBMChR determines the degree of parasympathetic effects on visceral organs.

Keywords

acetylcholine, M-cholinergic receptors, endogenous modulators of M-cholinergic receptors, endogenous modulators of alpha- and beta-adrenergic receptors, smooth muscles, coronary vessels, myocardium, pregnancy

References

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