UDC

612.821–053.9+574.24+57.045+159.91

Authors

Irina S. Deputat*, Irina N. Deryabina*, Aleksandra N. Nekhoroshkova*, Anatoliy V. Gribanov*
*Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russian Federation)
Corresponding author: Irina Deputat, address: proezd Badigina 3, Arkhangelsk, 163045, Russian Federation;
e-mail: i.deputat@narfu.ru

Abstract

The article presents a review of current scientific approaches to human ageing in the North. Ageing is a burning issue both in Russia and the rest of the world. To preserve body functions in older adults living in harsh climate is becoming increasingly important. The number of research on ecological physiology and polar medicine has been growing continually. However, we need to systematize the available scientific data and develop clear theoretical and practical solutions to the problems of human life in the North. The paper dwells on the ecological factors adversely affecting human health in the North and contributing to the development of polar stress syndrome. Further, it presents the results of the research into certain mechanisms accelerating ageing processes in the North due to disturbance of neuroendocrine regulation. In addition, it describes the research on the link between premature ageing and accelerated development of cardiovascular diseases, as well as on the shift of growing morbidity and mortality rates in non-native inhabitants of the North to the young and middle working age, etc. Special attention is paid to the influence of psycho-emotional stress on northerners during ageing. Further, the article presents data on the link between the efficiency of adaptation to adverse climatic and ecological factors of high latitudes and functional brain asymmetry. Moreover, the importance of research into the mechanisms of human adaptation and maladjustment in the North is highlighted here, as it reflects peculiarities of the formation of pathological conditions, thus helping to prevent them in the elderly and old age.

Keywords

climatic and ecological conditions of the North, older adults, ageing, polar stress syndrome, northern stress, brain asymmetry, brain energy state

References

1. Belkin V., Korostishevsky M., Batsevich V., Pavlovsky O., Volkov-Dubrovin V., Kobyliansky E. Morpho- Physiological Features of Human Populations in the Context of Climatic – Geographical Conditions. Coll. Antropol., 2012, vol. 36, no. 3, pp. 729–743. 
2. Hunter R.H., Anderson L.A., Belza B., Bodiford K., Hooker S.P., Kochtitzky C.S., Marquez D.X., Satariano W.A. Environments for Healthy Aging: Linking Prevention Research and Public Health Practice. Prev. Chronic Dis., 2013, vol. 10. Art. no. 120244. 
3. Parnachev A.A. Aktual’nost’ problem strategicheskogo razvitiya severnykh territoriy [Current Importance of the Problems of Strategic Development of Northern Territories]. Korporativnoe upravlenie i innovatsionnoe razvitie ekonomiki Severa, 2005, no. 4, pp. 94–97. Available at: http://koet.syktsu.ru/vestnik/2005/2005-4/25.htm (accessed 2 March 2017). 
4. Chashchin V.P., Khar’kova T.L., Kvasha E.A., Bogoyavlenskiy D.D., Tronin A.A., Tokarevich N.K., Buzinov R.V., Kershengol’ts B.M., Chernyavskiy V.F., Nikiforov O.I., Repin V.E. Vliyanie global’nykh klimaticheskikh izmeneniy na zdorov’e naseleniya rossiyskoy Arktiki [The Impact of Global Climate Change on the Health of the Population of the Russian Arctic]. Moscow, 2008. 28 p. Available at: http://www.unrussia.ru/sites/default/files/doc/Arctic-ru.pdf (accessed 24 May 2017). 
5. Gudkov A.B., Lukmanova N.B., Ramenskaya E.B. Chelovek v pripolyarnom regione Evropeyskogo Severa: ekologo-fiziologicheskie aspekty [Human in the Circumpolar Region of the European North: Ecological and Physiological Aspects]. Arkhangelsk, 2013. 181 p. 
6. Boyko E.R. Fiziologo-biokhimicheskie osnovy zhiznedeyatel’nosti cheloveka na Severe [Physiological and Biochemical Bases of Human Life in the North]. Yekaterinburg, 2005. 190 p. 
7. Boyko E.R. (ed.). Problemy adaptatsii cheloveka k ekologicheskim i sotsial’nym usloviyam Severa [Problems of Human Adaptation to the Ecological and Social Conditions of the North]. St. Petersburg 2009. 268 p. 
8. Jungmann H. Response to Meteorological Stress as a Function of Age. Experientia, 1987, vol. 43, no. l, pp. 54–57. 
9. Fauzer V.V. Naselenie i demograficheskoe razvitie Severa Rossii [The Population and Demographic Development of the Russian North]. Sever kak ob”ekt kompleksnykh regional’nykh issledovaniy [North as an Object of Integrated Regional Studies]. Syktyvkar, 2005, pp. 96–101. 
10. Nikitin Yu.P., Khasnulin V.I., Gudkov A.B. Sovremennye problemy severnoy meditsiny i usiliya uchenykh po ikh resheniyu [Contemporary Problems of Northern Medicine and Researchers’ Efforts to Solve Them]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Mediko-biologicheskie nauki, 2014, no. 3, pp. 63–72. 
11. Avtsyn A.P., Zhavoronkov A.A., Marachev A.G., Milovanov A.P. Patologiya cheloveka na Severe [Human Pathology in the North]. Moscow, 1985. 415 p. 
12. Agadzhanyan N.A., Ermakova N.V. Ekologicheskiy portret cheloveka na Severe [Ecological Portrait of Human in the North]. Moscow, 1997. 206 p. 
13. Deryapa N.R., Ryabinin I.F. Adaptatsiya cheloveka v polyarnykh rayonakh Zemli [Human Adaptation in the Polar Regions of the Earth]. Leningrad, 1977. 296 p. 
14. Kaznacheev V.P., Kulikov V.Yu., Panin L.E., Sokolov V.P., Lyakhovich V.V., Shorin Yu.P., Mayanskiy D.N. Mekhanizmy adaptatsii cheloveka v usloviyakh vysokikh shirot [The Mechanisms of Human Adaptation to High Latitudes]. Leningrad, 1980. 200 p. 
15. Gribanov A.V. Dinamika krovoobrashcheniya u shkol’nikov v usloviyakh Evropeyskogo Severa: avtoref. dis. … d-ra med. nauk [Haemodynamics in Schoolchildren in the European North: Dr. Med. Sci. Diss. Abs.]. Arkhangelsk, 1991. 38 p. 
16. Khasnulin V.I., Khasnulin P.V. Sovremennye predstavleniya o mekhanizmakh formirovaniya severnogo stressa u cheloveka v vysokikh shirotakh [Modern Concepts of the Mechanisms Forming Northern Stress in Humans in High Latitudes]. Ekologiya cheloveka, 2012, no. 1, pp. 3–11. 
17. Kochan T.I., Shadrina V.D., Potolitsyna N.N., Eseva T.V., Ketkina O.A., Bubnova N.S. Integrated Evaluation of the Influence of a Northern Environment on Human Metabolism and Physiological and Psychoemotional States. Hum. Physiol., 2008, vol. 34, no. 3, pp. 356–362. 
18. Gudkov A.B., Popova O.N., Pashchenko A.V. Fiziologicheskie reaktsii cheloveka na lokal’noe kholodovoe vozdeystvie [Human Physiological Responses to Local Cooling]. Arkhangelsk, 2012. 143 p. 
19. Mashanov A.A., Bulygin G.V. Izmenenie nekotorykh regulyatornykh parametrov organizma cheloveka v protsesse adaptatsii k ekologicheskim usloviyam Kraynego Severa [Changes in Some Regulatory Parameters of the Human Body During Adaptation to the Ecological Conditions of the Far North]. Vestnik Krasnoyarskogo gosudarstvennogo agrarnogo universiteta, 2006, no. 10, pp. 170–172. 
20. Panin L.E. Gomeostaz i problemy pripolyarnoy meditsiny (metodologicheskie aspekty alaptatsii) [Homeostasis and Problems of Circumpolar Health (Methodological Aspects of Adaptation)]. Byulleten’ Sibirskogo otdeleniya RAMN, 2010, vol. 30, no. 3, pp. 6–11. 
21. Sormunen E. Repetitive Work in the Cold. Work Ability, Musculoskeletal Symptoms and Thermal and Neuromuscular Responses in Food Industry Workers. Acta Univ. Oul., D Medica, 2009, iss. 1023. Available at: http:// jultika.oulu.fi/files/isbn9789514292040.pdf (accessed 7 July 2017). 
22. Ermolin S.P. Kharakteristiki gemodinamicheskikh pokazateley i fizicheskoy rabotosposobnosti u voennosluzhashchikh v Arktike v kontrastnye sezony goda [Features of Hemodynamic Parameters of Physical Efficiency in the Military in Contrasting Seasons of the Year]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Estestvennye nauki, 2014, no. 4, pp. 75–80. 
23. Gribanov A.V., Danilova R.I. Obshchaya kharakteristika klimato-geograficheskikh usloviy Russkogo Severa i adaptivnykh reaktsiy cheloveka v kholodnoy klimaticheskoy zone (obzor) [General Characteristics of Climatic and Geographical Conditions of the Russian North and Human Adaptive Responses in the Cold Climatic Zone]. Sever. Deti. Shkola [North. Children. School]. Arkhangelsk, 1994, pp. 4−27. 
24. Soroko S.I., Aldasheva A.A. Individual Strategies of Human Adaptation Under Extreme Conditions. Hum. Physiol., 2012, vol. 38, no. 6, pp. 626−633. 
25. Beloborodova G.S., Beloborodova V.F. Adaptatsionnye izmeneniya sostoyaniya zdorov’ya zhiteley Kraynego Severa pod vozdeystviem okhlazhdayushchego faktora sredy [Adaptational Changes in the Health of the Far North Residents Exposed to a Cooling Environmental Factor]. Problemy ekologii cheloveka: sb. nauch. st. po materialam Vseros. konf. s mezhdunar. uchastiem [Problems of Human Ecology: Proc. All-Rus. Sci. Conf. with Int. Particip.]. Arkhangelsk, 2000, pp. 15–20. 
26. Korolenko Ts.P. Psikhofiziologiya cheloveka v ekstremal’nykh usloviyakh [Human Psychophysiology in Extreme Conditions]. Leningrad, 1978. 272 p. 
27. Dushkova D.O., Evseev A.V. Ekologiya i zdorov’e cheloveka: regional’nye issledovaniya na evropeyskom Severe Rossii [Ecology and Human Health: Regional Studies in the European North of Russia]. Moscow, 2011. 192 p. 
28. Hasnulin V.I., Hasnulina A.V., Sevostyanova E.V. Northern Cardiometeopathies. Novosibirsk, 2004. 220 p. 
29. Maksimov A.L., Golubev V.N., Nosov V.N. Podkhody k otsenke regional’noy normy reaktsii i adaptatsii fiziologicheskikh sistem organizma u cheloveka na Severe [Approaches to Assessment of the Regional Norm of Response and Adaptation of Human Physiological Systems in the North]. Vestnik Dal’nevostochnogo otdeleniya RAN, 2007, no. 6, pp. 56–64. 
30. Young T.K., Chatwood S. Health Care in the North: What Canada Can Learn from Its Circumpolar Neighbours. CMAJ, 2011, vol. 183, no. 2, pp. 209–214. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033925/ (accessed 7 July 2017). 
31. Anikina N.Yu. Raspredelenie urovnya postoyannogo potentsiala u inostrannykh studentov, nachavshikh obuchenie v severnykh vuzakh (na primere g. Arkhangel’ska) [Distribution of DC Potential Level in Foreign Students Arrived in the Conditions of High Latitudes (Arkhangelsk)]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Mediko-biologicheskie nauki, 2016, no. 1, pp. 5–12. 
32. Bittel J.H. Heat Debt as an Index for Cold Adaptation in Men. J. Appl. Physiol., 1987, vol. 62, no. 4, pp. 1627–1634. 
33. Agadzhanyan N.A., Konovalova G.M., Ozheva R.Sh., Urakova T.Yu. Vozdeystvie vneshnikh faktorov na formirovanie adaptatsionnykh reaktsiy organizma cheloveka [The Effect of External Factors on the Formation of Adaptive Reactions in Human Body]. Novye tekhnologii, 2010, no. 2, pp. 142–144. 
34. Voroshilova I.I., Efanov V.N. Otsenka vozdeystviya prirodno-klimaticheskikh faktorov okruzhayushchey sredy na zdorov’e naseleniya Sakhalinskoy oblasti [Estimation of Influence of Natural Climatic Factors of an Environment on Health of the Elderly Population of the Sakhalin Area]. Uchenye zapiski Sakhalinskogo gosudarstvennogo universiteta, 2012, no. 1, pp. 64–69. 
35. Solonin Yu.G., Chermnykh N.A. Fiziologicheskie pokazateli muzhchin Severa pri starenii [Physiological Indices in Men Living in the North at Ageing]. Klinicheskaya gerontologiya, 1999, no. 4, pp. 59–63. 
36. Hasnulin V., Kulikov V., Sobakin A., Hasnulina A., Chechetkina I., Selyatitskaya V., Polyuhovitch V., Kim L. Premature Aging Processes in the North. Proc. 13th Int. Congr. Circumpolar Health. Novosibirsk, 12–16 June 2006. Novosibirsk, 2006. Available at: http://www.ict.nsc.ru/ws/show_abstract.dhtml?en+125+9105 (accessed 20 June 2017). 
37. Hasnulin V.I., Voytik I.M., Hasnulina A.V., Ryabichenko T.I., Skosyreva G.A. Some Ethnic Features of Northern Aborigines’ Psychophysiology as a Base for Survival in Extreme Natural Conditions: A Review. Available at: http:// www.scirp.org/jouRNAl/PaperInformation.aspx?PaperID=47569 (accessed 20 June 2017). 
38. Khasnulin V.I., Chechetkina I.I., Khasnulin P.V., Sobakin A.K. Ekologicheski obuslovlenyy stress i starenie cheloveka na Severe [Ecology-Related Stress and Ageing in the North]. Ekologiya cheloveka, 2006, suppl. 4/1, pp. 16–21. 
39. Chechetkina I.I. Osobennosti protsessov stareniya trudosposobnogo naseleniya na Severe: dis. … kand. med. nauk [Peculiarities of Ageing Processes in the Able-Bodied Population in the North: Cand. Med. Sci. Diss.]. Novosibirsk, 2007. 113 p. 
40. Wyndham C.H., Fellingham S.A. Climate and Disease. S. Afr. Med. J., 1998, vol. 53, no. 26, pp. 1051–1061. 
41. Duffy L., Gerlach C., Ebbesson S., Young K., Dewailly E., Bjerregaard P., Dunlap K.L., Godduhn A., Reynolds A.J. Arctic Medical Health, Disease and Nutrition: The Challenges and the Joys. Int. J. Circumpolar Health, 2013, vol. 72, p. 841. 
42. Varlamova N.G., Evdokimov V.G. Changes in Electrocardiographic Parameters in Males of the European North as Markers of Climate- and Age-Related Effects. Hum. Physiol., 2002, vol. 28, no. 6, pp. 737–742. 
43. Bundzen P.V. Izmenenie funktsional’noy organizatsii nervnykh protsessov v vysshikh otdelakh golovnogo mozga cheloveka v period polyarnoy nochi [Changes in the Functional Organization of Neural Processes in Human Cortex and Subcortex During the Polar Night]. Byulleten’ sovetskoy antarkticheskoy ekspeditsii, 1969, vol. 74, pp. 29–35. 
44. Aristova V.V., Bychikhin N.P., Pashchenko V.P. Osobennosti adaptatsii cheloveka k usloviyam Evropeyskogo Severa [Peculiarities of Human Adaptation to the Conditions of the European North]. Sistemy adaptatsii cheloveka i vneshnyaya sreda [Human Adaptation Systems and the External Environment]. Leningrad, 1975, pp. 29–30. 
45. Juvani S., Isola A., Kyngäs H. The Northern Physical Environment and the Well-Being of the Elderly Aged over 65 Years. Int. J. Circumpolar Health, 2005, vol. 64, no. 3, pp. 246–256. 
46. Fokin V.F., Ponomareva N.V. Energeticheskaya fiziologiya mozga [Energy Physiology of the Brain]. Moscow, 2003. 288 p. 
47. Nekhoroshkova A.N., Gribanov A.V. Raspredelenie urovnya postoyannogo potentsiala golovnogo mozga u mladshikh shkol’nikov s vysokoy trevozhnost’yu [Distribution of DC Potential Level in Primary School Children with High Level of Anxiety]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Mediko-biologicheskie nauki, 2015, no. 3, pp. 30–36. 
48. Gribanov A.V., Deputat I.S. Distribution of the DC-Potential Level in the Brain of Older Women in the Circumpolar Region. Hum. Physiol., 2015, vol. 41, no. 3, pp. 342–343. 
49. Deputat I.S., Gribanov A.V., Bol’shevidtseva I.L. Osobennosti energeticheskogo obmena golovnogo mozga u zhitel’nits Evropeyskogo Severa Rossii v pozhilom vozraste (na primere Arkhangel’skoy oblasti) [Cerebral Energy Metabolism in Older Women Living in the European North of Russia (Exemplified by the Arkhangelsk Region)]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Mediko-biologicheskie nauki, 2016, no. 4, pp. 5–12. 
50. Khasnulin V.I., Khasnulina A.V. Psikhoemotsional’nyy stress i meteoreaktsiya kak sistemnye proyavleniya dizadaptatsii cheloveka v usloviyakh izmeneniya klimata na Severe Rossii [Psycho-Emotional Stress and Meteoreacton as Systemic Manifestations of Human Disadaptation Under Changing Climatic Conditions in the North of Russia]. Ekologiya cheloveka, 2012, no. 8, pp. 3–7. 
51. Erickson K.I., Colcombe S.J., Wadhwa R., Bherer L., Peterson M.S., Scalf P.E., Kim J.S., Alvarado M., Kramer A.F. Training-Induced Plasticity in Older Adults: Effects of Training on Hemispheric Asymmetry. Neurobiol. Aging, 2007, vol. 28, no. 2, pp. 272–283. 
52. Ponomareva N.V., Fokin V.F., Orlov O.A., Selezneva N.D., Pavlova O.A. Stress i narushenie psikhofiziologicheskogo sostoyaniya cheloveka pri starenii [Stress and Disorders in the Human Psychophysiological State at Ageing]. Problemy neyrokibernetiki: materialy 14-y Mezhdunar. konf. po neyrokibernetike [Problems of Neurocybernetics: Proc. 14th Int. Conf. on Neurocybernetics]. Rostov-on-Don, 2005. Vol. 1, pp. 207–208. 
53. Park D.C., Gutchess A.H. Aging, Cognition, and Culture: A Neuroscientific Perspective. Neurosci. Biobehav. Rev., 2002, vol. 26, no. 7, pp. 859–867. 
54. Peel N.M., McClure R.J., Bartlett H.P. Behavioral Determinants of Healthy Aging. Am. J. Prev. Med., 2005, vol. 28, no. 3, pp. 298–304. 
55. Leutin V.P. Nikolaeva E.I., Fomina E.V. Asimmetriya mozga i adaptatsiya cheloveka [Brain Asymmetry and Human Adaptation]. Available at: http://www.cerebral-asymmetry.narod.ru/Leutin_Pavlov2007.htm (accessed 10 July 2017). 
56. Hommet C., Destrieux C., Constans T., Berrut G. Aging and Hemispheric Cerebral Lateralization. Psychol. Neuropsychiatr. Vieil., 2008, vol. 6, no. 1, pp. 49–56. 
57. Kaznacheev V.P., Semenov S.V., Chuprikov A.P. (eds.). Funktsional’naya asimmetriya i adaptatsiya cheloveka [Functional Asymmetry and Human Adaptation]. Moscow, 1976. 318 p. 
58. Kulikov V.Yu., Antropova L.K., Kozlova L.A. Vliyanie funktsional’noy asimmetrii mozga na strategiyu povedeniya individa v stressovoy situatsii [The Effect of Functional Brain Asymmetry on Behaviour Strategies in Stressful Situations]. Meditsina i obrazovanie v Sibiri, 2010, no. 5, p. 10. 
59. Buduk-ool L.K., Nazyn-ool M.V. Funktsional’naya asimmetriya mozga i obuchenie: etnicheskie osobennosti [Functional Brain Asymmetry and Learning: Ethnic Characteristics]. Moscow, 2010. 143 p. 
60. Sevost’yanova E.V. Osobennosti funktsional’noy mezhpolusharnoy asimmetrii u zhiteley Severa s arterial’noy gipertoniey razlichnogo vozrasta [Peculiarities of Functional Interhemispheric Asymmetry in the Inhabitants of the North of Various Ages with Arterial Hypertension]. Sovremennye napravleniya issledovaniy funktsional’noy mezhpolusharnoy asimmetrii i plastichnosti mozga: materialy Vseros. konf. s mezhdunar. uchastiem [Current Trends in the Studies of Functional Interhemispheric Asymmetry and Plasticity of the Brain: Proc. All-Rus. Conf. with Int. Particip.]. Moscow, 2–3 December 2010, pp. 241–245. 
61. Stepanov Yu.M. Rol’ funktsional’noy asimmetrii mozga v regulyatsii psikhofiziologicheskogo sostoyaniya cheloveka pri adaptatsii k usloviyam Kraynego Severa: avtoref. dis. … kand. biol. nauk [The Role of Functional Brain Asymmetry in the Regulation of Human Psychophysiological State During Adaptation to the Conditions of the Far North: Cand. Biol. Sci. Diss. Abs.]. Novosibirsk, 1988. 18 p. 
62. Pavlov K.I., Kamenskaya V.G. Vozdeystvie ekologicheskikh faktorov na spektral’nye kharakteristiki dinamicheskoy funktsional’noy asimmetrii mozga cheloveka [The Influence of Ecological Factors on Spectral Characteristics of the Dynamic Encephalic Asymmetry]. Psikhologiya obrazovaniya v polikul’turnom prostranstve, 2014, no. 27. Available at: http://www.elsu.ru/journal/issues/87/articles/1227 (accessed 24 May 2017). 
63. Dern S., Vogt T., Abeln V., Strüder H.K., Schneider S. Psychophysiological Responses of Artificial Gravity Exposure to Humans. Eur. J. Appl. Physiol., 2014, vol. 114, no. 10, pp. 2061–2071. 
64. Arshavskiy V.V., Gel’fgat E.A., Rotenberg B.C., Solovenchuk L.L. Mezhpolusharnaya asimmetriya kak faktor adaptatsii cheloveka v usloviyakh Severa [Interhemispheric Asymmetry as a Factor of Human Adaptation in the Conditions of the North]. Fiziologiya cheloveka, 1989, vol. 15, no. 5, pp. 142–146.