UDC

612.111.44:615.373.34

Authors

Viktor I. Tsirkin*/**, Aleksandr D. Nozdrachev***, Konstantin Yu. Anisimov****, Svetlana L. Dmitrieva*****, Ol’ga A. Bratukhina*****, Svetlana V. Khlybova******
*Kazan State Medical University (Kazan, Russian Federation)
**Vyatka State University (Kirov, Russian Federation)
***Saint Petersburg State University (St. Petersburg, Russian Federation)
****Ural State Medical University (Yekaterinburg, Russian Federation)
*****Kirov Regional Clinical Perinatal Centre (Kirov, Russian Federation)
******Kirov State Medical University (Kirov, Russian Federation)
Corresponding author: Viktor Tsirkin, address: ul. Butlerova 49, Kazan, 420012, Russian Federation / ul. Moskovskaya 36, Kirov, 610000, Russian Federation; e-mail: tsirkin@list.ru

Abstract

The final part of this review concludes that women during pregnancy and labour experience changes in the background properties of erythrocytes in venous blood and their response to adrenaline, acetylcholine, oxytocin, serotonin, progesterone, estrogen and other biologically active substances, i.e. changes in activation efficiency of corresponding G-protein-coupled receptors (GPRs). It is hypothesized that these changes, which are indicators of the course of pregnancy and labour, occur due to the activation of membrane progesterone and estrogen receptors and as a result of changes in blood levels of endogenous GPR modulators (such as endogenous sensitizer of beta-adrenergic receptors). The article suggests a classification of the indicators of erythrocyte functional state in terms of diagnosing threatened preterm labour (TPL) and evaluating the probability of TPL transition to preterm labour (PL). It consists of four groups: 1) uninformative indicators (8) whose values do not change during pregnancy, labour and in the presence of TPL; 2) indicators (9) whose values in women with TPL are the same as in parturients but differ from those observed in women without TPL; these indicators confirm the presence of TPL but do not allow us to estimate the probability of TPL transition to PL; 3) indicators (9) whose values in women with TPL are the same as in women without TPL but differ from those in parturients; they do not allow us to confirm the presence of TPL, but give grounds for evaluation of the risks of TPL transition to PL; 4) indicators (1) whose values in women with TPL differ from those in women without TPL and parturients; they allow us to diagnose TPL and assess the risks of TPL transition to PL. Thе latter group includes the ОRE_DW45 index, which reflects the effect of adrenaline (10^-10–10^-6 g/ml) on the osmotic resistance of erythrocytes at their 45-second exposure in distilled water.

Keywords

erythrocyte functional state, indicators of threatened preterm labour, erythrocyte osmotic resistance, erythrocyte sedimentation, erythrocyte aggregation, erythrocyte agglutination

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