UDC

612.67+577.24

Authors

Lena B. Kim*, Petr M. Kozhin*, Anna N. Putyatina*
*Research Institute of Experimental and Clinical Medicine (Novosibirsk, Russian Federation)
Corresponding author: Lena Kim, address: ul. Timakova 2, Novosibirsk, 630117, Russian Federation;
e-mail: lenkim@centercem.ru

Abstract

When studying the ageing process, researchers tend to associate the revealed structural and functional shifts with the chronological (calendar, passport) age, which does not always reflect the general state of health. In the Arctic, human physiological ageing and adaptation to climatic and geographical factors in combination with factors of industrial production are simultaneous processes having joint impact on the human body. Today, a huge number of ageing markers is known. However, clinical trials more often assess the biological age, treating it as an indicator of the general state of health, adaptability to extreme exposures and degree of ageing. The existing contradictory results of the evaluation of the biological age of the people living in the Russian Arctic prove that new informative markers of ageing are required. This is the first time that the expression of p16^INK4A molecular biomarker of ageing using real-time polymerase chain reaction was studied for this purpose. This biomarker is known as cyclindependent kinase inhibitor CDKN2A, participating in the regulation of the cell cycle by slowing down the transition from G1- to S-phase. The paper revealed increased expression of this biomarker in men living and working in the European North of Russia. The intensity of expression depended on the age and duration of living in the North. It was higher in individuals older than 40 years and in those who had lived in the Arctic for more than 20 years. The p16^INK4A biomarker of ageing positively correlated with the chronological and biological age of northerners. Thus, it can be used as a biomarker of human premature ageing in the Russian Arctic.

Keywords

Arctic, European North of Russia, duration of living in the Arctic, ageing, chronological age, biological age, p16INK4A biomarker of ageing

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