UDC

[612.82+612.017.1]-612.06

Authors

Zinaida V. Galasheva*, Liliya V. Poskotinova**
*Federal Centre for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
**Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russian Federation)
Corresponding author: Liliya Poskotinova, address: 249 prosp. Lomonosova, Arkhangelsk, 163000, Russian Federation; e-mail: liliya200572@mail.ru

Abstract

This paper presents a review of literature on the physiological role of pro- and anti-inflammatory cytokines, predominantly interleukin-6 (IL-6) and interleukin-10 (IL-10), in the functioning of the nervous system during different age periods. It is shown here that both deficient and excessive secretion of cytokines in the peripheral blood and brain structures in humans and animals at the early stages of ontogeny determines its further cognitive and emotional development as well as the risk of pathology of the central nervous system during the pre- and postnatal periods, adolescence and mature age. Further, pathological conditions are pointed out, whose development can be attributed to a possible role of neuro-immune disorders, including those formed at the early stages of ontogeny: cerebral palsy, autism, schizophrenia, hyperactivity, depression, psychosis, epilepsy, Parkinson’s disease, Alzheimer’s disease, meningitis, stroke and diabetes. It has been shown that the success of biofeedback of the autonomic regulation of cardiac activity in humans depends on the IL-6 level in the peripheral blood. In addition, we summarized literature data on the state of pro- and anti-inflammatory cytokines in the peripheral blood of northerners and their role in the formation of regional pathology. A possible adaptive role of proand anti-inflammatory cytokines, exemplified by IL-6 and IL-10, was identified in the formation of brain activity during adolescence and throughout one’s life to maintain homeostasis in the human body in an uncomfortable environment.

Keywords

cytokines, interleukin-6, interleukin-10, central nervous system

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