UDC

[612.015.32-053.2/6:577.164.11](470.1/.2+571.651)

Authors

Ol’ga S. Vlasova*, Fatima A. Bichkaeva*, Tat’yana V. Tret’yakova*
*Federal Center for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Ol’ga Vlasova, address: prosp. Lomonosova 249, Arkhangelsk, 163061, Russian Federation; e-mail: olgawlassova@mail.ru

Abstract

Living in the North entails changes in the metabolic profile and formation of certain vitamin deficiencies, including thiamine. Their detrimental effect is especially pronounced in children and adolescents. Our study involved children and adolescents aged 10–17 years living in the European and Asian North of Russia, in the Subarctic and Arctic regions. The spectrophotometric method was used to determine the levels of carbohydrate metabolism parameters (glucose, pyruvate, and lactate) and thiamine levels (TPP effect) in the blood. According to the values of TPP effect, the subjects were divided into groups with high vitamin B₁ levels, normal vitamin B₁ levels, mild thiamine deficiency, and severe thiamine deficiency. In the Subarctic region, we observed significant changes in carbohydrate metabolism parameters in the group with high thiamine levels, which is manifested in decreased pyruvate levels and increased LAC/PYR ratio values. At the same time, in the Arctic region, statistically significant glucose fluctuations were recorded in children and adolescents with mild thiamine deficiency. Increased glucose levels can be a result of inhibition of glycolysis and activation of gluconeogenesis due to inhibition of the pyruvate dehydrogenase complex. The paper shows that living in areas with varying extreme natural, climatic and weather conditions, due to the formation of certain metabolic responses (in the Arctic region – decreased glucose level and less expressed accumulation of lactate in the blood), results in multidirectional influence of thiamine levels on carbohydrate metabolism parameters.

Keywords

carbohydrate metabolism, thiamine level, thiamine deficiency, children and adolescents in the Russian North

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