UDC

612.11

Authors

Yuliya V. Malysheva*, Irina A. Tikhomirova*, Elena P. Petrochenko*
*Yaroslavl State Pedagogical University named after K.D. Ushinsky (Yaroslavl, Russian Federation)

Abstract

The effectiveness of peripheral blood flow is largely determined by blood rheology and functional activity of platelets. Changes in the properties of blood cells can lead to a decrease in blood fluidity, blockage of parts of the capillary network, and tissue hypoxia; in cancer, these changes increase the risk of thrombotic complications. This study examined the venous blood of practically healthy volunteer donors (n = 33; mean age 24.9 ± 7.8 years) and patients of the Yaroslavl Regional Cancer Hospital (n = 14; mean age 62.8 ± 8.7 years) with kidney cancer. We evaluated a set of rheological properties of blood, platelet aggregation activity and transport capacity of blood. The haemorheological profile of this disease is characterized by a reduction in the number of red blood cells, a compensatory increase in blood plasma viscosity and a decrease in oxygen delivery index. We observed an increase in erythrocyte and platelet aggregation in kidney cancer. Erythrocyte aggregates in cancer patients are distinguished by their large size and considerable resistance to shear flow. Such characteristics of erythrocyte aggregates, along with increased aggregation activity of platelets, at decreased oxygen delivery index contribute to the formation of tissue hypoxia in patients. Negative changes in the microrheological properties of blood cells can be considered to be a pathological link in the development of malignant tumours. The revealed characteristics of erythrocyte and platelet properties serve as additional evidence of the high risk of thrombotic complications in kidney cancer.

Keywords

kidney cancer, blood viscosity, plasma viscosity, haematocrit, erythrocyte aggregation, platelet aggregation

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