UDC

[612.13+612.261]:796

DOI

10.17238/issn2542-1298.2019.7.3.251

Authors

Al’bina Z. Dautova*, Valentina G. Shamratova**, Elena V. Vorob’eva***
*Bashkir Institute of Physical Culture (Branch) of the Urals State University of Physical Culture (Ufa, Republic of Bashkortostan, Russian Federation)
**Bashkir State University (Ufa, Republic of Bashkortostan, Russian Federation)
***Bashkir State Pedagogical University named after M. Akmulla (Ufa, Republic of Bashkortostan, Russian Federation)
Corresponding author: Al’bina Dautova, address: ul. Kommunisticheskaya 67, Ufa, 450077, Respublika Bashkortostan, Russian Federation; e-mail: dautova.az@mail.ru

Abstract

This article studies the association of polymorphic variants rs4646994 (I/D) of the ACE gene, rs1800875 (-1903A>G) of the CMA1 gene, and rs5810761 (+9/-9) of the BDKRB2 gene with a number of parameters of the oxygen transport system in young men with different levels of motor activity. The following indicators were assessed: blood system – red blood cell count, haemoglobin level, haematocrit, mean red blood cell volume, mean haemoglobin concentration, and mean corpuscular haemoglobin concentration; haemodynamics – blood pressure, heart rate, and cardiac output; integral indicators of the cardiovascular system – myocardial stress index, level of physical condition, endurance coefficient, and coefficient of economization of blood circulation. Tissue oxygen availability was evaluated by the p50 indicator (O2 voltage at 50 % blood desaturation). It was shown that physically inactive young men with the *I allele of the ACE gene are characterized by a more economical functioning of the cardiovascular system, as well as by a more efficient regulation of haemoglobin’s affinity for oxygen. Physically inactive young men having the *+9 allele of the BDKRB2 gene in their genotype are characterized by the hyperkinetic type of blood circulation and low tolerance to physical exertion. In the group of athletes, the *G allele of the CMA1 gene plays a protective role, improving reserve and compensatory capacities of the cardiovascular system. Based on a joint correlation analysis of three polymorphic variants of the ACE, CMA1 and BDKRB2 genes, a conclusion is made about the influence of the alleles *I, *G and *-9 on the state of red blood cells in athletes: an increase in the number of these alleles in the genotype is associated with a decrease in quantitative blood indicators (red blood cell count) and an increase in qualitative blood indicators (mean red blood cell volume and mean corpuscular haemoglobin concentration).

Keywords

genetic polymorphism, motor activity, oxygen transport system, red blood cells, haemodynamics

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