UDC

612.14:575.174.015.3

DOI

10.17238/issn2542-1298.2019.7.4.371

Authors

Natal’ya A. Bebyakova* ORCID: 0000-0002-9346-1898
Sergey N. Levitskiy* ORCID: 0000-0003-2588-620X
Ol’ga A. Pervukhina* ORCID: 0000-0002-7585-0793
Irina A. Shabalina* ORCID: 0000-0001-9425-3882
*Northern State Medical University (Arkhangelsk, Russian Federation)
Corresponding author: Irina Shabalina, address: prosp. Troitskiy 51, Arkhangelsk, 163000, Russian Federation; e-mail: ira_sha@mail.ru

Abstract

Angiotensin II receptor type 1 realizes the peptide’s vasoconstrictive effect; as a result, the AGT2R1 gene encoding the synthesis of this receptor is considered to be a candidate gene involved in the formation of cardiovascular pathology, including hypertension. The A1166C polymorphism in the 3’ untranslated region is the most extensively studied polymorphism, whose presence in the genome is associated with increased gene expression and the development of hypertension. Published data show that the studies on the А1166С polymorphism mainly involved subjects diagnosed with cardiovascular pathologies, which makes it impossible to assess the role of early manifestations of risk factors in people with this polymorphism in order to prognosticate and prevent the pathology under study. This paper investigates the effect of the А1166С polymorphism in young healthy people born in the Arkhangelsk Region on the formation of cardiovascular risk factors and the levels of vasoactive endothelial factors. It was revealed that the presence of two CC polymorphic alleles in the genome was accompanied by instability of the average dynamic pressure in response to physical activity and a decrease in adaptation potential of the cardiovascular system, indicating that the cardiovascular system is under functional stress. Moreover, we found an association between the CC genotype and the hypertensive response to graduated exercise based on increasing peripheral resistance. CC genotype carriers demonstrated imbalance in vasoactive endothelial factors characterized by an increase in endothelin-1 vasoconstrictor levels and a decrease in the vasodilator/vasoconstrictor index. The data obtained allow us to consider the 1166СС genotype of the AGT2R1 gene to be a predictor of cardiovascular disease in young people born in the Arkhangelsk Region.

Keywords

A1166C polymorphism of the AGT2R1 gene, angiotensin II receptor type 1 gene, cardiovascular risk factors, endothelial vasoactive factors

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