UDC

616-056.52

DOI

10.17238/issn2542-1298.2019.7.4.452

Authors

Kseniya D. Ievleva* ORCID:0000-0002-0177-234X
Tat’yana A. Bairova* ORCID:0000-0003-3704-830X
Ekaterina A. Sheneman*,
Zhanna G. Ayurova** ORCID: 0000-0002-9100-8360
Varvara V. Bal’zhieva***,
Evgeniya A. Novikova* ORCID: 0000-0002-9353-7928
Ol’ga V. Bugun* ORCID: 0000-0002-2162-3683
Lyubov’ V. Rychkova* ORCID:0000-0002-0117-2563
Lyubov’ I. Kolesnikova* ORCID: 0000-0003-3354-2992
*Scientific Сentre for Family Health and Human Reproduction Problems (Irkutsk, Russian Federation)
**Kurumkan Central District Hospital (Republic of Buryatia, Russian Federation)
***City Outpatient Clinic No. 6 (Ulan-Ude, Republic of Buryatia, Russian Federation)
Corresponding author: Kseniya Ievleva, address: ul. Timiryazeva 16, Irkutsk, 664003, Russian Federation; e-mail: asiy91@mail.ru   

Abstract

Obesity is a complex disease contributing to the development of metabolic disorders, including lipid metabolism disorders. All metabolic processes in the body are determined by certain genes, whose polymorphisms can increase the risk of pathologies, such as diabetes mellitus, hypertension, atherosclerosis, etc. One of these polymorphisms is the PPARG2 gene locus (rs1801282; Pro12Ala), which shows contradictory results in different races and ethnic groups. This research aimed to study the prevalence of PPARG2 Pro12Ala in Caucasoid (Russian) and Mongoloid (Buryat) adolescents, as well as estimate the association between this locus and lipid parameters. A total of 395 adolescents (mean age 14.7±1.75 years; 187 boys and 208 girls) participated in the study. They were divided into 4 groups: Caucasoid adolescents with normal body mass (n = 94) and overweight/obese (n = 101), Mongoloid adolescents with normal body mass (n = 110) and overweight/obese (n = 90). Anthropometric (body mass, height, body mass index standard deviation) and biochemical measurements (total cholesterol, triglycerides, high density lipoproteins, low density lipoproteins, and atherogenic coefficient) as well as molecular genetic testing were performed. In the Mongoloid sample we observed significant differences both in terms of genotype frequency (СС, СG, and GG genotypes were found in 58.2, 25.5, and 16.3 % of cases in adolescents with normal body mass and in 73.6, 24.1, and 2.2 % of cases in overweight and obese subjects; р = 0.00004) and in terms of allele frequency (G-allele frequency was 29.1 and 14.4 % in subjects with normal body mass and overweight adolescents, respectively; р = 0.001) of PPARG2 Pro12Ala polymorphism. We found a significant association of G-allele with a decrease in triglyceride level (р = 0.029) and in atherogenic coefficient, as well as with a decrease in the level of high density lipoproteins among Mongoloid adolescents. Thus, Mongoloid adolescents show a protective effect of G-allele of the PPARG2 Pro12Ala polymorphic locus against overweight and obesity

Keywords

obesity, overweight, adolescents, lipid metabolism, PPARG2, Caucasoids, Mongoloids

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