UDC

[612.4:577.175.44](985)(045)

DOI

10.17238/issn2542-1298.2020.8.1.14

Authors

Irina N. Gorenko* ORCID: 0000-0003-3097-9427
*N. Laverov Federal Center for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Irina Gorenko, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation; e-mail: pushistiy-86@mail.ru   

Abstract

This article analyses the significance and prevalence of thyroid autoantibodies in healthy people of different ethnic groups living in the Arctic zone of the Russian Federation. The study involved 325 apparently healthy subjects, divided into groups according to their ethnicity and level of serum autoantibodies. Serum hormones of the pituitary-thyroid system, thyroglobulin, anti-thyroid peroxidase antibodies (anti-TPO) and thyroglobulin antibodies (anti-TG) concentrations were measured by enzyme-linked immunosorbent assay. The analysis of the thyroid function test in the groups with different levels of thyroid antibodies showed that the thyroid-stimulating hormone concentration and the prevalence of its elevated values (> 2.5 µIU/l) were statistically significantly higher in the group of individuals with positive thyroid antibodies (i.e. anti-TPO ≥ 50 IU/ml and/or anti-TG ≥ 100 IU/ml) compared to the subjects with negative antibodies (i.e. anti-TPO < 50 IU/ml and/ or anti-TG < 100 IU/ml). The proportion of individuals with positive thyroid antibodies in the general population of the Arctic zone of the Russian Federation was 16.4 %. The thyroid function test showed statistically significantly lower levels of thyroid-stimulating hormone and anti-TPO in Russians compared with the Nenets, the latter being characterized by significantly higher thyroxine, triiodothyronine and thyroglobulin levels against the background of lower free thyroxine and anti-TG concentrations compared to Russians and the Komi. The prevalence of positive thyroid antibodies among Russians and the Nenets was identical (17.3 %), while in the Komi it was 4.3 %. The paper demonstrates significant positive correlations of thyroid antibodies with the thyroid-stimulating hormone, and negative – with thyroglobulin.
For citation: Gorenko I.N. Thyroid Hormones and Autoantibodies in Representatives of Different Ethnic Groups Living in the Arctic Zone of the Russian Federation. Journal of Medical and Biological Research, 2020, vol. 8, no. 1, pp. 14–22. DOI: 10.17238/issn2542-1298.2020.8.1.14

Keywords

thyroglobulin antibodies, anti-thyroid peroxidase antibodies, thyroid-stimulating hormone, thyroglobulin, thyroxine, triiodothyronine, the Nenets, the Komi

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