UDC

616.379-008.64

DOI

10.17238/issn2542-1298.2020.8.1.45

Authors

Kristina A. Cherepanova* ORCID: 0000-0003-4644-8065
Vladimir I. Korchin* ORCID:0000-0002-1818-7550
Elena A. Ugorelova** ORCID: 0000-0002-1903-0483
Tat’yana Ya. Korchina* ORCID: 0000-0002-2000-4928
*Khanty-Mansiysk State Medical Academy (Khanty-Mansiysk, Khanty-Mansi Autonomous Okrug – Yugra, Russian Federation)
**Khanty-Mansiysk District Clinical Hospital (Khanty-Mansiysk, Khanty-Mansi Autonomous Okrug – Yugra, Russian Federation)
Corresponding author: Kristina Cherepanova, address: ul. Mira 40, Khanty-Mansiysk, 628011, Khanty-Mansi Autonomous Okrug – Yugra, Russian Federation; e-mail: k_gorobtsova@mail.ru

Abstract

Diabetes mellitus remains the most widespread disease among the numerоus types of endocrine pathology. Despite significant progress in treatment, its morbidity is constantly increasing. In recent years, a large amount of data has been accumulated indicating that the effect of vitamin D extends far beyond the bone tissue. For instance, a link has been found between vitamin D deficiency and diabetes. Vitamin D regulates the fat and glucose metabolism: its deficiency is associated with insulin resistance, glucose tolerance, as well as excessive accumulation of adipose tissue. Vitamin D is ingested with food, mainly with animal products (fatty fish, fish oil, and milk), and is also produced in the skin under the influence of sunlight. The main factor determining the severity of vitamin D deficiency is the region’s geographical location; regions with low insolation are located above 40°N. Using the method of chemiluminescent enzyme immunoassay on paramagnetic particles with original reagents for the Architect i2000SR analyser, we quantified the serum 25(OH)D levels of 132 adult residents of Khanty-Mansiysk. Of these, 78 (59.1 %) patients had type 2 diabetes and 54 (40.9 %) were relatively healthy volunteers. Their mean age was 53.6 ± 1.1 years. The results were evaluated in accordance with the recommendations of the International Society of Endocrinology (2011). We found no statistically significant differences in vitamin D status between the groups. A pronounced vitamin D deficiency occurred in 58 people (73.4 %) with type 2 diabetes.
For citation: Cherepanova K.A., Korchin V.I., Ugorelova E.A., Korchina T.Ya. Vitamin D Levels in Patients with Type 2 Diabetes Living in the Khanty-Mansi Autonomous Okrug. Journal of Medical and Biological Research, 2020, vol. 8, no. 1, pp. 45–53. DOI: 10.17238/issn2542-1298.2020.8.1.45

Keywords

northern regions of Russia, type 2 diabetes mellitus, vitamin D deficiency, risk factors for cardiovascular disease

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