UDC

[612.12:577.125](571.121)

DOI

10.17238/issn2542-1298.2020.8.1.54

Authors

Boris A. Shengof* ORCID: 0000-0002-3776-1474
Fatima A. Bichkaeva* ORCID: 0000-0003-2970-4469
Sergey V. Andronov** ORCID: 0000-0002-5616-5897
*N. Laverov Federal Center for Integrated Arctic Research, Russian Academy of Sciences (Arkhangelsk, Russian Federation)
*Arctic Research Center (Yamalo-Nenets Autonomous Okrug, Salekhard, Russian Federation)
Corresponding author: Boris Shengof, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation; e-mail: b-shengof@yandex.ru

Abstract

This paper presents the results of a comparative analysis of phosphatidylserine, sphingomyelin, phosphatidylcholine and phosphatidylethanolamine content in the peripheral blood of the able-bodied population of the Yamalo-Nenets Autonomous Okrug at different levels of ω-6 fatty acids. The research was conducted in the period from 2015 to 2018 and involved 254 subjects aged between 22 and 60 years (mean age (M±SD) 43.25±10.05 years) born and permanently residing in the aforementioned area. Serum phospholipid concentrations were determined after preliminary lipid extraction by means of thin-layer chromatography. The next stage included methylation of the lipid extract followed by the production of fatty acid methyl esters. The content of ω-6 polyunsaturated fatty acids was determined by gas-liquid chromatography. As variables for subsequent analysis we used the sums of ω-6 fatty acids. According to the concentrations of ω-6 fatty acids, the subjects were divided into three groups: 1) 718.31–1052.82 μg/ml; 2) 433.44–718.31 μg/ml; 3) 1052.82–1198.06 μg/ml. Based on the results of the nonparametric analysis of variance, statistically significant differences in sphingomyelin and phosphatidylcholine were established between the groups, while phosphatidylserine and phosphatidylethanolamine levels showed no such differences. Post hoc comparisons revealed that in persons with a high content of ω-6 fatty acids (1052.82–1198.06 μg/ml) the proportion of sphingomyelin in the total pool of serum phospholipids decreases, which, in its turn, leads to a relative increase in the percentage of phosphatidylcholine.
For citation: Shengof B.A., Bichkaeva F.A., Andronov S.V. phospholipid profile at different ω-6 fatty acids levels in the blood serum of the Able-Bodied Population of the Yamalo-Nenets Autonomous Okrug. Journal of Medical and Biological Research, 2020, vol. 8, no. 1, pp. 54–60. DOI: 10.17238/issn2542-1298.2020.8.1.54

Keywords

phosphatidylserine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, ω-6 fatty acids, population of the Yamalo-Nenets Autonomous Okrug

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