UDC

612.017.1:612.014.4(470.1/2)

DOI

10.37482/2687-1491-Z014

Authors

Ol’ga S. Morozova* ORCID: 0000-0002-9587-2500
Tat’yana B. Sergeeva* ORCID: 0000-0003-0745-3099
Lyubov’ S. Shchegoleva* ORCID: 0000-0003-4900-4021
*N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Ol’ga Morozova, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation; e-mail: olia.morozow2011@yandex.ru

Abstract

Extreme climatic and ecological conditions in the Far North impede the self-regulation processes that optimize the functioning of the human body, which leads to the activation of the cellular and humoral branches of the immune system and puts them under pressure, thus, ultimately, reducing the body’s reserve capacity. Aim: to identify the peculiarities of cellular immunity in 40–60-year-old women living in the Far North. Materials and methods. We examined 116 women aged 40–60 years, 49 of them living in Pinega settlement, Arkhangelsk Region (expeditions of 2010–2011), 27 living in Nes village, Nenets Autonomous Okrug (expeditions of 2009–2011), and 40 living in the town of Nadym, Yamalo-Nenets Autonomous Okrug (expedition of 2015). The immunological examination involved evaluating the content of lymphocytes with CD10+, CD16+, CD71+, and CD95+ receptors. The content of T lymphocyte subpopulations was determined by double-peroxidase labelling using monoclonal antibodies (MedBioSpektr Research and Production Centre, Russia) on dried-droplet lymphocyte preparations. The cells were counted using immersion microscopy (Nikon Eclipse 50i). Results. We found that cellular immunity experiences stress due to insufficient apoptotic activity (CD95+) in 43.96 ± ± 0.56 % of the examined women against the background of increased cytotoxic activity (CD16+) in the same population (43.96 ± 0.56 %) and increased lymphoproliferative activity (CD10+) in 19.29 ± 0.37 % of the subjects. This condition in women aged 40–60 years is fraught with the development of clinical forms of secondary immunodeficiency due to environmental factors and can manifest itself through various chronic pathologies. Conclusion. The revealed deficiency of cellular immunity in women aged 40–60 years in 19 to 43 % of cases (depending on the indicator) may be the cause of destructive processes increasing the duration of diseases and exacerbating their course and outcome.

Keywords

Far North, lymphocyte phenotypes, cells with receptors to apoptosis, natural killer cells, immune status, women aged 40–60 years

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