UDC

[616-055.1:577.175](470.11)

DOI

10.37482/2687-1491-Z015

Authors

Viktoriya A. Popkova* ORCID: 0000-0002-0818-7274
*N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Viktoriya Popkova, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation; e-mail: victoria-popcova@yandex.ru

Abstract

The climatic and geographical conditions in the European North of Russia form a specific state of health and pathology requiring high functional and adaptive potential of the body. The working environment of pulp and paper industry exacerbates the adverse action of the natural factors on the endocrine status of the population. In this regard, the socio-medical significance of evaluating and preventing the consequences of the combined effects of natural and production factors in industrialized territories continues to grow. In the North, the body’s homeostatic regulation leads to the activation of the thyroid system. This article presents the results of comparative studies on the content of thyroxin-binding globulin, thyroid hormones and their ratio in the blood of Arkhangelsk residents not working in industries with adverse factors and employees of the pulp and paper mill. The periods of 1989–1990 and 2009– 2012 were investigated. It is demonstrated here that over the twenty-year period, changes occurred in the thyroid hormones profile and ratios in the male population of the city of Arkhangelsk, i.e. the peripheral conversion of iodothyronines increased against the background of a general decrease in the concentrations of thyroid hormones and their transporter in those examined in 2009–2012. At the same time, employees of the pulp and paper mill have higher levels of serum thyroxine and lower concentrations of triiodothyronine, thyroxin-binding globulin, and ratio of iodothyronines compared with men not involved in industries with extreme working conditions, regardless of the year of research.

Keywords

thyroxine, triiodothyronine, thyroxine-binding globulin, peripheral conversion index, working age men, pulp and paper production, North

References

1. Tkachev A.V., Ramenskaya E.B. Ekologo-fiziologicheskie osobennosti sistemy gipofiz-kora nadpochechnikov-shchitovidnaya zheleza [Ecophysiological Features of the Pituitary-Adrenal-Thyroid System]. Tkachev A.V., Boyko E.R., Gubkina Z.D., Ramenskaya E.B., Sukhanov S.G. Endokrinnaya sistema i obmen veshchestv u cheloveka na Severe [The Endocrine System and Metabolism in Humans Living in the North]. Syktyvkar, 1992, pp. 15–44.
2. Tipisova E.V., Kipriyanova K.E., Gorenko I.N., Lobanov A.A., Popov A.I., Andronov S.V., Popkova V.A., Elfimova A.E. Soderzhanie dofamina i gormonov sistemy gipofiz–shchitovidnaya zheleza v krovi u kochuyushchego, osedlogo i mestnogo naseleniya Arktiki [The Content of Dopamine and Hormones of System “Hypophysis–Thyroid” in Blood of Nomadic, Settled and Local Population of the Arctic]. Klinicheskaya laboratornaya diagnostika, 2017, vol. 62, no. 5, pp. 291–296. DOI: 10.18821/0869-2084-2017-62-5-291-296
3. Gorenko I.N., Tipisova E.V., Popkova V.A., Elfimova A.E. Ratios of the Hormones of the Pituitary–Thyroid Axis, Dopamine and cAMP in Residents of the European and Asian North of Russia. J. Med. Biol. Res., 2019, vol. 7, no. 2, pp. 140–150. DOI: 10.17238/issn2542-1298.2019.7.2.140
4. Korchin V.I. Osobennosti tireoidnogo statusa vzroslogo naseleniya Khanty-Mansiyskogo avtonomnogo okruga – Yugry v zavisimosti ot etnicheskoy prinadlezhnosti [Ethnicity-Related Thyroid Status in the Adult Population, KhantyMansi Autonomous Okrug – Yugra]. Vestnik Surgutskogo gosudarstvennogo universiteta, 2016, no. 3, pp. 77–81.
5. Levy S.B., Leonard W.R., Tarskaia L.A., Klimova T.M., Fedorova V.I., Baltakhinova M.E., Krivoshapkin V.G., Snodgrass J.J. Seasonal and Socioeconomic Influences on Thyroid Function Among the Yakut (Sakha) of Eastern Siberia. Am. J. Hum. Biol., 2013, vol. 25, no. 6, pp. 814–820.
6. Kolesnikova L.I., Darenskaya M.A., Grebenkina L.A., Sholokhov L.F., Rashidova M.A., Dolgikh M.I., Semenova N.V., Mikhalevich I.M. Tireoidnyy status i vitaminy-antioksidanty u devushek razlichnykh etnosov [Thyroid Status and Antioxidant Vitamins in the Girls of Different Ethnic Groups]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova, 2015, vol. 101, no. 2, pp. 214–221.
7. Bartosh T.P., Maksimov A.L. Vliyanie prirodno-ekologicheskikh faktorov Severa na gormonal’nyy status rabochikh, zanyatykh v podzemnoy zolotodobyche [Influence of Climatic-Ecological Factors of the North on Hormonal Status of the Miners Occupied in Underground Gold-Mining]. Ekologiya cheloveka, 2003, no. 1, pp. 10–12.
8. Trofimova E.A., Kireeva V.V. Osobennosti tireoidnoy patologii u rabotnikov tsellyuloznogo proizvodstva [Peculiarities of Thyroid Pathology in Workers of Pulp Manufacture]. Sibirskiy meditsinskiy zhurnal, 2010, vol. 97, no. 6, pp. 211–214.
9. Amino N., Yabu Y., Miki T., Morimoto S., Kumahara Y., Mori H., Iwatani Y., Nishi K., Nakatani K., Miyai K. Serum Ratio of Triiodothyronine to Thyroxine, and Thyroxine-Binding Globulin and Calcitonin Concentrations in Graves’ Disease and Destruction-Induced Thyrotoxicosis. J. Clin. Endocrinol. Metab., 1981, vol. 53, no. 1, pp. 113–116.
10. Trukhacheva N.V. Matematicheskaya statistika v mediko-biologicheskikh issledovaniyakh s primeneniem paketa Statistica [Mathematical Statistics in Biomedical Research Using the Statistica Package]. Moscow, 2013. 384 p.
11. Revich B.A. Klimaticheskie izmeneniya kak novyy faktor riska dlya zdorov’ya naseleniya rossiyskogo Severa [Climatic Changes as a New Risk Factor for Population Health in the Russian North]. Ekologiya cheloveka, 2009, no. 6, pp. 11–16.
12. Tipisova E.V. Funktsional’naya aktivnost’ shchitovidnoy i polovykh zhelez v usloviyakh Evropeyskogo Severa [Functional Activity of the Thyroid Gland and Gonads in the European North]. XXI s”ezd Fiziologicheskogo obshchestva imeni I.P. Pavlova [21st Congress of I.P. Pavlov Physiologist Society]. Moscow, 2010, p. 605.
13. Refetoff S. Thyroid Hormone Serum Transport Proteins. Feingold K.R., Anawalt B., Boyce A., et al. (eds.). Endotext. South Dartmouth, 2000. Available at: https://www.ncbi.nlm.nih.gov/books/NBK285566/ (accessed: 17 June 2020).
14. Popkova V.A. Dinamika pokazateley endokrinnogo profilya rabochikh tsellyulozno-bumazhnogo kombinata [Changes in Endocrine Profile of Workers in Pulp and Paper Plant]. Meditsina truda i promyshlennaya ekologiya, 2017, no. 3, pp. 54–59.
15. Hassol S.J. Impacts of a Warming Arctic: Arctic Climate Impact Assessment. Cambridge University Press, 2004. 140 p.
16. Parry M., Canziani O., Palutikof J., van der Linden P., Hanson C. (eds.). Climate Change 2007: Adaptation and Vulnerability. Cambridge University Press, 2007. 986 p.