UDC

577.125:[615.357:665.345.4]

DOI

10.37482/2687-1491-Z044

Authors

Irina S. Sobolevskaya* ORCID: 0000-0001-8300-7547
Oleg D. Myadelets* ORCID: 0000-0001-8796-052X
Natalʼya N. Yarotskaya* ORCID: 0000-0002-2493-7653
*Vitebsk State Order of Peoplesʼ Friendship Medical University
(Vitebsk, Republic of Belarus)
Corresponding author: Irina Sobolevskaya, address: prosp. Frunze 27, Vitebsk, 210009, Republic of Belarus; e-mail: irinabelikovavgmu@yandex.ru

Abstract

The purpose of this study was to substantiate the possibility of correcting lipid metabolism changes at dark deprivation using linseed oil, melatonin, and their combination. Materials and methods. The experiment involved 130 white outbred male rats with a body weight of 170–220 g. The animals were divided into 5 groups: rats under standard fixed lighting conditions (12 hours light/12 hours dark); rats under modelled dark deprivation with round-the-clock lighting (24 hours light); rats under modelled dark deprivation with round-the-clock lighting (24 hours light) receiving intragastric injections of linseed oil, melatonin or their combination from day 1 of the experiment. Serum concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total phospholipids (TPL) and atherogenic index (AI) were determined. Results. Long-term dark deprivation led to dyslipoproteinemia, which consists in an increase in serum concentrations of TC by a factor of 1.33 (p = 0.0009), TG by a factor of 1.62 (p = 0.013), LDL-C by a factor of 1.2 (p = 0.026) and TPL by a factor of 1.15 (p = 0.0082). The severity of changes in TC, TG, LDL-C, HDL-C and TPL concentrations varied depending on the duration of the experiment. During the use of linseed oil, melatonin or their combination under dark deprivation, the severity of disorders caused by desynchronosis decreased and lipid metabolism in rat serum normalized, especially at the initial stages of the research. Conclusion. Changes in lipid metabolism due to desynchronosis in rats injected with the substances under study were significantly smaller compared with animals that did not receive them. The most pronounced effects of administering these substances were observed in the group of rats treated with linseed oil and melatonin at the same time. 
For citation: Sobolevskaya I.S., Myadelets O.D., Yarotskaya N.N. Influence of Melatonin and Linseed Oil on the State of Lipid Metabolism at Desynchronosis in Rats. Journal of Medical and Biological Research, 2021, vol. 9, no. 1, pp. 58–68. DOI: 10.37482/2687-1491-Z044

Keywords

dark deprivation, desynchronosis, lipid metabolism, serum lipid profile, correction of lipid metabolism disorders, melatonin, linseed oil

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