UDC

631.41:574(470.67)

DOI

10.37482/2687-1491-Z045

Authors

Patimat M. Ibnumaskhudova* ORCID: 0000-0002-5952-148X
Patimat D. Kazanbieva* ORCID: 0000-0002-8236-5155
Umiyat A. Magomedova* ORCID: 0000-0002-4939-2637
Khadizhat N. Abdurazakova* ORCID: 0000-0003-2560-0320
Zarema Z. Surkhaeva* ORCID: 0000-0001-8160-1673
Sevdet S. Ibragimova* ORCID: 0000-0001-6695-3566
*Dagestan State Medical University
(Makhachkala, Republic of Dagestan, Russian Federation)
Corresponding author: Umiyat Magomedova, address: ul. Sh. Alieva 1, Makhachkala, Republic of Dagestan, 367000, Russian Federation; e-mail: m.umijat@yandex.ru

Abstract

Neurological and endocrine diseases, being widespread and producing significant impact on peopleʼs health as well as increasing the risk of disability of the working population (thus burdening the state budget), remain a most important medical and economic problem today. The study aimed to establish a link between these pathologies and the content of trace elements (cobalt, copper, zinc and manganese) in the soils of Dagestan plains. The concentration of active forms of cobalt, copper, zinc and manganese in the soil was established using the atomic absorption spectrophotometer model 170-70 (Hitachi, Japan) at the Biogeochemistry Laboratory of the Caspian Institute of Biological Resources, Dagestan Federal Research Centre, Russian Academy of Sciences. To determine the morbidity rate in the population, we turned to the data of the Ministry of Health of the Republic of Dagestan. The study revealed that the relevant pathologies in Dagestanʼs population, leading to disability, are caused by the trace element composition of the soil. Having compared the data on the content of cobalt, copper, zinc and manganese in the soils of the republicʼs lowland districts (Kizilyurt, Khasavyurt, Babayurt) and the prevalence of endocrine and neurological pathologies, we found a high correlation. The number of patients was in direct proportion to the content of manganese and in inverse proportion to the content of cobalt, copper and zinc. However, in Kizlyar District endocrine pathologies only correlated with zinc in the soil, which, apparently, can be explained by the local diet, fish products playing an important role, and by the fact that the territory is often flooded with coastal waters, changing the elementsʼ concentration in the soil.
For citation: Ibnumaskhudova P.M., Kazanbieva P.D., Magomedova U.A., Abdurazakova Kh.N., Surkhaeva Z.Z., Ibragimova S.S. Concentration of Certain Trace Elements in the Soils of Dagestan Lowlands and Its Medical and Ecological Significance. Journal of Medical and Biological Research, 2021, vol. 9, no. 1, pp. 69–76. DOI: 10.37482/2687- 1491-Z045

Keywords

trace element content in the soil, cobalt, copper, zinc, manganese, endocrine diseases, neurological disorders, correlation coefficient

References

1. Abeywickarama B., Ralapanawa U., Chandrajith R. Geoenvironmental Factors Related to High Incidence of Human Urinary Calculi (Kidney Stones) in Central Highlands of Sri Lanka. Environ. Geochem. Health, 2015, vol. 38, no. 5, pp. 1203–1214. DOI: 10.1007/s10653-015-9785-x
2. Cabral Pinto M.M.S., Marinho-Reis A.P., Almeida A., Ordens C.M., Silva M.M.V.G., Freitas S., Simões M.R., Moreira P.I., Dinis P.A., Diniz M.L., Ferreira da Silva E.A., Condesso de Melo M.T. Human Predisposition to Cognitive Impairment and Its Relation with Environmental Exposure to Potentially Toxic Elements. Environ. Geochem. Health, 2018, vol. 40, no. 5, pp. 1767–1784. DOI: 10.1007/s10653-017-9928-3
3. Leslie D.L., Lyons W.B. Variations in Dissolved Nitrate, Chloride, and Sulfate in Precipitation, Reservoir, and Tap Waters, Columbus, Ohio. Int. J. Environ. Res. Public Health, 2018, vol. 15, no. 8. Art. no. 1752. DOI: 10.3390/ijerph15081752
4. Cabral Pinto M.M.S., Ferreira da Silva E.A. Heavy Metals of Santiago Island (Cape Verde) Alluvial Deposits: Baseline Value Maps and Human Health Risk Assessment. Int. J. Environ. Res. Public Health, 2018, vol. 16, no. 1. Art. no. 2. DOI: 10.3390/ijerph16010002
5. Timofeev I., Shartova N., Kosheleva N., Kasimov N. Potentially Toxic Elements in Urban Topsoils and Health Risk Assessment for the Mining W–Mo Center in the Baikal Region. Environ. Geochem. Health, 2019, vol. 42, no. 1, pp. 221–240. DOI: 10.1007/s10653-019-00340-4
6. Bini C. Urban Soils and Human Health. EQA Int. J. Environ. Quality, 2019, vol. 33, pp. 1–10. DOI: 10.6092/issn.2281-4485/8529
7. Krężel A., Maret W. The Biological Inorganic Chemistry of Zinc Ions. Arch. Biochem. Biophys., 2016, vol. 611, pp. 3–19. DOI: 10.1016/j.abb.2016.04.010
8. Marreiro D.D., Cruz K.J., Morais J.B., Beserra J.B., Severo J.S., de Oliveira A.R. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel), 2017, vol. 6, no. 2. Art. no. 24. DOI: 10.3390/antiox6020024
9. Atrián-Blasco E., Gonzalez P., Santoro A., Alies B., Faller P., Hureau C. Cu and Zn Coordination to Amyloid Peptides: From Fascinating Chemistry to Debated Pathological Relevance. Coord. Chem. Rev., 2018, vol. 375, pp. 38–55. DOI: 10.1016/j.ccr.2018.04.007
10. Van Cleave C., Crans D.C. The First-Row Transition Metals in the Periodic Table of Medicine. Inorganics, 2019, vol. 7, no. 9. Art. no. 111. DOI: 10.3390/inorganics7090111
11. Khayat S., Fanaei H., Ghanbarzehi A. Minerals in Pregnancy and Lactation: A Review Article. J. Clin. Diagn. Res., 2017, vol. 11, no. 9, pp. QE01–QE05. DOI: 10.7860/jcdr/2017/28485.10626
12. Begun D.N., Morozova T.A., Surikova A.V. Bolezni nervnoy sistemy kak mediko-sotsialʼnaya problema [Diseases of the Nervous System as a Medical and Social Problem ]. Molodoy uchenyy, 2019, no. 10, pp. 78–80.
13. Govbakh I.A. Populyatsionno-epidemiologicheskie aspekty nasledstvennykh bolezney nervnoy sistemy [Population-Epidemiology Aspects of the Hereditary Diseases of the Nervous System]. ScienceRise, 2015, vol. 2, no. 4, pp. 54–60. DOI: 10.15587/2313-8416.2015.38184
14. Kuznetsov E.V., Zhukova L.A., Pakhomova E.A., Gulamov A.A. Endokrinnye zabolevaniya kak medikosotsial ʼnaya problema sovremennosti [Endocrine Diseases as a Medical-Social Problem of Today]. Sovremennye problemy nauki i obrazovaniya, 2017, no. 4, pp. 62–70.
15. Metodicheskie ukazaniya po opredeleniyu mikroelementov v pochvakh, kormakh i rasteniyakh metodom atomno-absorbtsionnoy spektroskopii [Guidelines for Determininig Trace Elements in the Soils, Forage and Plants by Means of Atomic Absorption Spectroscopy]. Moscow, 1985. 95 p.
16. Merzlyakova A.Yu. Vliyanie ekogeneticheskikh faktorov na cheloveka [Influence of Ecogenetic Factors on Humans]. Molodoy uchenyy, 2020, no. 7, pp. 283–286.
17. Abusuev S.A., Yakhiyaev M.A., Salikhov Sh.K., Kazanbieva P.D. Soderzhanie yoda v pochvakh i pitʼevykh vodakh Dagestana i rasprostranennostʼ epidemicheskogo zoba [Iodine in Soils and Drinking Waters of Dagestan and the Prevalence of Endemic Goiter]. Problemy zhenskogo zdorovʼya, 2016, vol. 11, no. 1, pp. 26–31.
18. Salikhov Sh.K., Yakhiyaev M.A., Abusuev S.A., Isakhanova M.M. Vliyanie mikroelementov pochv i vodoistochnikov na zdorovʼe naseleniya ravninnoy zony Dagestana [Influence of Trace Elements in Soil and Water Sources on the Health of the Population of Dagestan Lowlands]. Aridnye ekosistemy, 2017, vol. 23, no. 2, pp. 68–71.
19. Luganova S.G., Yakhiyaev M.A., Salikhov Sh.K., Gamzaeva A.U. Vliyanie ryada mikroelementov v pochvakh i prirodnykh vodakh Dagestana na zdorovʼe naseleniya [Effect of Several Trace Elements in Soils and Water of Dagestan on Public Health]. Mikroelementy v meditsine, 2018, vol. 19, no. 3, pp. 41–48. DOI: 10.19112/2413-6174-2018-19-3-41-48
20. Sostoyanie zdorovʼya naseleniya Respubliki Dagestan v 2014 godu [The Health of the Population of the Republic of Dagestan in 2014]. Makhachkala, 2015. Available at: https://rmiac.ru/statistika/sborniki-o-sostoianiizdorovia-naseleniia-respubliki-dagestan (accessed: 20 December 2020).
21. Suslikov V.L. Geokhimicheskaya ekologiya bolezney. T. 3. Atomovitozy [Geochemical Ecology of Diseases. Vol. 3. Atomovitosis]. Moscow, 2002. 670 p.