UDC

[612.43:577-053.8+676](470.11)(045)

DOI

https://doi.org/10.37482/2687-1491-Z061

Authors

Viktoriya A. Alikina* ORCID: https://orcid.org/0000-0002-0818-7274
Elena V. Tipisova* ORCID: https://orcid.org/0000-0003-2097-3806
Aleksandra E. Elfimova* ORCID: https://orcid.org/0000-0003-2519-1600
*N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russian Federation)
Corresponding author: Viktoriya Alikina, address: prosp. Lomonosova 249, Arkhangelsk, 163000, Russian Federation; e-mail: victoria-popcova@yandex.ru

Abstract

Introduction. Maintaining good health and working capacity of the population is one of the main tasks of the healthcare system. Living under adverse climatic conditions of the North and being exposed to dangerous production factors of the pulp and paper industry, strongly represented in the Arkhangelsk Region, can significantly reduce the adaptive capacity of the body. Major role in providing an adequate response to the action of irritators and initiating the adaptation process is played by the neuroendocrine, cardiovascular, and circulatory systems, which reflect qualitative and quantitative changes in the body while being reliable markers of homeostasis. The aim was to study the adaptive potential of workers showing the level of functioning of the circulatory system and to evaluate their endocrine profile depending on the revealed functional capabilities of the body. Materials and methods. The study involved 50 men aged 22–60 years working in the production departments of Solombala Pulp and Paper Mill (Arkhangelsk) with a body mass index of 19–25 and without earlier history of endocrine pathology. Serum levels of thyroxine-binding globulin and oestradiol were determined by means of radioimmunoassay, while serum concentrations of total cortisol, thyrotropin, thyroxine, triiodothyronine, progesterone, testosterone, insulin, C-peptide, and somatotropin were determined by enzyme-linked immunosorbent assay. Results. The research demonstrated that in 2/3 of the examined employees of the pulp and paper mill the adaptation mechanisms were under strain, while the condition of two subjects corresponded to the physiological norm, which is characterized by good and satisfactory adaptation. Workers with decreased adaptive capabilities to the point of unsatisfactory adaptation showed increased levels of cortisol, thyroxine-binding globulin, oestradiol, C-peptide, and insulin against the background of a decrease in testosterone, progesterone, and the testosterone/oestradiol ratio. The authors recommend conducting periodic medical examinations of pulp and paper workers, including endocrine profile assessment, and monitoring changes that occur over time.
For citation: Alikina V.A., Tipisova E.V., Elfimova A.E. Adaptive Potential and Endocrine Profile of Pulp and Paper Workers in Arkhangelsk. Journal of Medical and Biological Research, 2021, vol. 9, no. 3, pp. 237–247. DOI: 10.37482/2687-1491-Z061

Keywords

adaptive potential, hormones, endocrine profile, working age men, pulp and paper industry, European North of Russia

References

1. Boyko E.R. Metodicheskie podkhody k issledovaniyu vliyaniya faktorov Severa na organizm cheloveka [Method Approaches to Studying Effects of North Factors on Human Body]. Vestnik obrazovaniya i razvitiya nauki Rossiyskoy akademii estestvennykh nauk, 2020, no. 1, pp. 82–88. DOI: 10.26163/RAEN.2020.46.81.013
2. Khasnulin V.I., Khasnulin P.V. Sovremennye predstavleniya o mekhanizmakh formirovaniya severnogo stressa u cheloveka v vysokikh shirotakh [Modern Concepts of the Mechanisms Forming Northern Stress in Humans in High Latitudes]. Ekologiya cheloveka, 2012, no. 1, pp. 3–11.
3. Kurzanov A.N., Zabolotskikh N.V., Kovalev D.V. Funktsional’nye rezervy organizma [Body’s Functional Reserves]. Moscow, 2016. 96 p.
4. Farrace S., Cenni P., Tuozzi G., Casagrande M., Barbarito B., Peri A. Endocrine and Psychophysiological Aspects of Human Adaptation to the Extreme. Physiol. Behav., 1999, vol. 66, no. 4, pp. 613–620. DOI: 10.1016/s0031-9384(98)00341-2
5. Kaznacheev V.P., Kulikov V.Yu., Panin L.E., Sokolov V.P., Lyakhovich V.V., Shorin Yu.P., Mayanskiy D.N. Mekhanizmy adaptatsii cheloveka v usloviyakh vysokikh shirot [The Mechanisms of Human Adaptation to High Latitudes]. Leningrad, 1980. 200 p.
6. Selye H. Stress in Health and Disease. London, 2013. 1300 p.
7. Kubasov R.V., Barachevsky Y.E., Ivanov A.M., Kubasova E.D., Lupachev V.V. Interhormonal Correlations at Professional Risk Staffs. Int. J. Biomed., 2019, vol. 9, no. 2, pp. 187–189.
8. Tipisova E.V., Kipriyanova K.E., Gorenko I.N., Lobanov A.A., Popov A.I., Andronov S.V., Popkova V.A., Elfimova A.E. Soderzhanie dofamina i gormonov sistemy gipofiz-shchitovidnaya zheleza v krovi u kochuyushchego, osedlogo i mestnogo naseleniya Arktiki [The Content of Dopamine and Hormones of System “Hypophysis-Thyroid” in Blood of Nomadic, Settled and Local Population of the Arctic]. Klinicheskaya laboratornaya diagnostika, 2017, vol. 62, no. 5, pp. 291–296. DOI: 10.18821/0869-2084-2017-62-5-291-296
9. Bets L.V. Gormonal’nye aspekty stareniya cheloveka (antropologicheskie i ekologicheskie podkhody) [Hormonal Aspects of Aging (Anthropological and Ecological Approaches)]. Vestnik Moskovskogo universiteta. Ser. 23: Antropologiya, 2013, no. 3, pp. 15–27.
10. Panin L.E. Adaptatsiya i pitanie cheloveka v ekstremal’nykh usloviyakh Arktiki [Adaptation and Human Nutrition in Extreme Conditions of the Arctic]. Innovatsii i prodovol’stvennaya bezopasnost’, 2013, no. 1, pp. 131–135.
11. Marotta V., Malandrino P., Russo M., Panariello I., Ionna F., Chiofalo M.G., Pezzullo L. Fathoming the Link
Between Anthropogenic Chemical Contamination and Thyroid Cancer. Crit. Rev. Oncol. Hematol., 2020, vol. 150. Art. no. 102950. DOI: 10.1016/j.critrevonc.2020.102950
12. Vanyushin Yu.S., Khayrullin R.R. Kompensatorno-adaptatsionnye reaktsii kardiorespiratornoy sistemy v ontogeneze pri funktsional’nykh nagruzkakh [Compensatory and Adaptation Responses of the Cardiorespiratory System in Ontogenesis During Functional Loads]. Nauka i sport: sovremennye tendentsii, 2015, vol. 7, no. 2, pp. 71–77.
13. Witvliet M.I., Toch-Marquardt M., Eikemo T.A., Mackenbach J.P. Improving Job Strain Might Reduce Inequalities in Cardiovascular Disease Mortality in European Men. Soc. Sci. Med., 2020, vol. 267. Art. no. 113219. DOI: 10.1016/j.socscimed.2020.113219
14. Solonin Yu.G., Boyko E.R. Mediko-fiziologicheskie aspekty zhiznedeyatel’nosti v Arktike [Medical and Physiological Aspects of Vital Activity in the Arctic]. Arktika: ekologiya i ekonomika, 2015, no. 1, pp. 70–75.
15. Baevskiy P.M., Berseneva A.P. Otsenka adaptatsionnykh vozmozhnostey organizma i risk razvitiya zabolevaniy [Assessing the Body’s Adaptation Potential and the Risk of Disease]. Moscow, 1997. 236 p.
16. Baranov V.M., Baevskiy R.M., Berseneva A.P., Mikhaylov V.M. Otsenka adaptatsionnykh vozmozhnostey organizma i zadachi povysheniya effektivnosti zdravookhraneniya [Evaluation of Adaptive Abilities of an Organism and Tasks of Healthcare Effectiveness Increase]. Ekologiya cheloveka, 2004, no. 6, pp. 25–29.
17. Shcherbinskaya E.S. Sokhranenie professional’nogo zdorov’ya – osnova nadezhnosti predpriyatiya [Preservation of Occupational Health Is the Basis for Reliability of the Enterprise]. Zdorov’e i okruzhayushchaya sreda [Health and Environment]. Minsk, 2019, pp. 172–174.
18. Sinyakova O.K., Zelenko A.V., Shcherbinskaya E.S., Semushina E.A. Donozologicheskaya diagnostika kak osnova zdorov’esberegayushchey strategii v organizatsii [Prenosological Diagnostics as the Basis of Health Saving Strategy in the Organization]. Zdorov’e i okruzhayushchaya sreda, 2018, no. 28, pp. 112–116.
19. Tkachev A.V., Boyko E.R., Gubkina Z.D., Ramenskaya E.B., Sukhanov S.G. Endokrinnaya sistema i obmen veshchestv u cheloveka na Severe [Endocrine System and Human Metabolism in the North]. Syktyvkar, 1992. 156 p.
20. Alenikova A.E. Endokrinnyy profil’ mestnykh i priezzhikh muzhchin – zhiteley g. Arkhangel’ska v razlichnye svetovye periody goda [Endocrine Status in Arkhangelsk Local Dwellers and Newcomers at Various Light Periods of the Year]. Ekologiya cheloveka, 2009, no. 7, pp. 56–60.
21. Fedina R.G., Khasnulin V.I. Issledovanie endokrinno-metabolicheskikh kharakteristik u prakticheski zdorovykh muzhchin-donorov Novosibirska [The Study of Endocrine-Metabolic Characterisic in Healthy Men-Donors of Novosibirsk]. Meditsina Kyrgyzstana, 2015, no. 2, pp. 43–45.
22. Popkova V.A. Vozrastnye osobennosti endokrinnogo statusa muzhchin – rabotnikov tsellyulozno-bumazhnogo kombinata g. Arkhangel’ska [Age-Related Features of the Endocrine Status in Arkhangelsk Pulp-and-Paper Industry Workers]. Ekologiya cheloveka, 2009, no. 7, pp. 37–41.
23. Popkova V.A. Dinamika pokazateley endokrinnogo profilya rabochikh tsellyulozno-bumazhnogo kombinata [Changes in Endocrine Profile of Workers in Pulp and Paper Plant]. Meditsina truda i promyshlennaya ekologiya, 2017, no. 3, pp. 54–59.
24. Gorenko I.N. Adaptatsionnyy potentsial i endokrinnyy profil’ muzhchin Arkhangel’ska [Adaptation Potential and Endocrine Profile in Male Residents of Arkhangelsk]. Ekologicheskie problemy severnykh regionov i puti ikh resheniya [Ecological Problems of the Northern Regions and Ways to Their Solution]. Apatity, 2019, pp. 392–393. DOI: 10.25702/KSC.978-5-91137-393-1
25. Giampapa V.C., Williamson M.E. Breaking the Aging Code: Maximizing Your DNA Function for Optimal Health and Longevity. North Bergen, 2004. 152 p.
26. Baevskiy R.M. Kontseptsiya fiziologicheskoy normy i kriterii zdorov’ya [Concept of Physiological Norm and Criteria of Health]. Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova, 2003, vol. 89, no. 4, pp. 473–487.