UDC

615.356+574.24(470.1/2)

DOI

10.37482/2687-1491-Z085

Authors

Galina N. Kostrova* ORCID: http://orcid.org/0000-0002-3132-6439
Svetlana I. Malyavskaya* ORCID: http://orcid.org/0000-0003-2521-0824
Andrey V. Lebedev* ORCID: http://orcid.org/0000-0003-1865-6748
*Northern State Medical University (Arkhangelsk, Russian Federation)
Corresponding author: Galina Kostrova, address: prosp. Troitskiy 51, Arkhangelsk, 163000, Russian Federation; e-mail: kostrovagn@yandex.ru

Abstract

Living in high latitudes is a risk factor for developing vitamin D deficiency. Literature data indicate that in the northern regions vitamin D cannot be synthesized in the skin for most of the year. It seems relevant to study vitamin D levels in the population of the Arctic zone of the Russian Federation during different seasons of the year, which was the purpose of our research. Materials and methods. We assessed 25(OH)D levels in 913 residents of the city of Arkhangelsk (64°N) in the course of three seasons: winter, spring, and autumn. The study included 191 children aged 7–8 years, of which 107 boys and 84 girls; 403 adolescents aged 13–17 years, of which 167 boys and 236 girls; 260 young people aged 18–22 years, of which 58 men and 202 women; 59 adults aged 24–65 years, of which 12 men and 47 women. Results. We revealed low vitamin D levels in residents of arkhangelsk qualifying as deficient throughout all three seasons. The median concentration of 25(OH)D was 16.3 (12.0–21.8) ng/ml in winter,16.9 (12.8–22.9) ng/ml in spring, and 15.8 (11.4–20.2) ng/ml in autumn. The proportion of subjects with a normal level of 25(OH)D wаs less than 1 % in winter, 8 % in spring, and 2 % in autumn. We revealed no dependence of 25(OH)D concentration on the average daylight duration or significant differences in 25(OH)D levels in different seasons of the year. Presumably, these results can be explained by the low amount of daylight hours spent outdoors by the subjects during the three seasons of the year. Further research is required on the contribution of various factors affecting 25(OH)D levels: length of time spent outdoors, level of physical activity, contribution of dietary sources of vitamin D.

Keywords

vitamin D level, vitamin D deficiency, 25(OH)D, seasons of the year, residents of the Arctic zone of the Russian Federation

References

1. Amrein K., Scherkl M., Hoffmann M., Neuwersch-Sommeregger S., Köstenberger M., Tmava Berisha A., Martucci G., Pilz S., Malle O. Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide. Eur. J. Clin. Nutr., 2020, vol. 74, no. 11, pp. 1498–1513. DOI: 10.1038/s41430-020-0558-y

2. Dominguez L.J., Farruggia M., Veronese N., Barbagallo M. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites, 2021, vol. 11, no. 4. Art. no. 255. DOI: 10.3390/metabo11040255

3. Gaksch M., Jorde R. Grimnes G., Joakimsen R., Schirmer H., Wilsgaard T., Mathiesen E.B., Njølstad I., Løchen M.L., März W., Kleber M.E., Tomaschitz A., Grübler M., Eiriksdottir G., Gudmundsson E.F., Harris T.B., Cotch M.F., Aspelund T., Gudnason V., Rutters F., Beulens J.W., van ‘t Riet E., Nijpels G., Dekker J.M., Grove-Laugesen D., Rejnmark L., Busch M.A., Mensink G.B., Scheidt-Nave C., Thamm M., Swart K.M., Brouwer I.A., Lips P., van Schoor N.M., Sempos C.T., Durazo-Arvizu R.A., Škrabáková Z., Dowling K.G., Cashman K.D., Kiely M., Pilz S. Vitamin D and Mortality: Individual Participant Data Meta-Analysis of Standardized 25-Hydroxyvitamin D in 26916 Individuals from a European Consortium. PLoS One, 2017, vol. 12, no. 2. Art. no. e0170791. DOI: 10.1371/journal.pone.0170791

4. Charoenngam N., Holick M.F. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, vol. 12, no. 7. Art. no. 2097. DOI: 10.3390/nu12072097

5. Nikooyeh B., Neyestani T.R. Oxidative Stress, Type 2 Diabetes and Vitamin D: Past, Present and Future. Diabetes Metab. Res. Rev., 2016, vol. 32, no. 3, pp. 260–267. DOI: 10.1002/dmrr.2718

6. Khasnulin V.I., Khasnulin P.V. Sovremennye predstavleniya o mekhanizmakh formirovaniya severnogo stressa u cheloveka v vysokikh shirotakh [Modern Concepts of the Mechanisms Forming Northern Stress in Humans in High Latitudes]. Ekologiya cheloveka, 2012, no. 1, pp. 3–11.

7. Chashchin V.P., Kovshov A.A., Gudkov A.B., Morgunov B.A. Sotsial’no-ekonomicheskie i povedencheskie faktory riska narusheniy zdorov’ya sredi korennogo naseleniya Kraynego Severa [Socioeconomic and Behavioral Risk Factors of Disabilities Among the Indigenous Population in the Far North]. Ekologiya cheloveka, 2016, no. 6, pp. 3–8. DOI: 10.33396/1728-0869-2016-6-3-8

8. Kozlov A., Khabarova Y., Vershubsky G., Ateeva Y., Ryzhaenkov V. Vitamin D Status of Northern Indigenous People of Russia Leading Traditional and “Modernized” Way of Life. Int. J. Circumpolar Health, 2014, vol. 73. Art. no. 26038. DOI: 10.3402/ijch.v73.26038

9. Nielsen N.O., Jørgensen M.E., Friis H., Melbye M., Soborg B., Jeppesen C., Lundqvist M., Cohen A., Hougaard D.M., Bjerregaard P. Decrease in Vitamin D Status in the Greenlandic Adult Population from 1987–2010. PLoS One, 2014, vol. 9, no. 12. Art. no. e112949. DOI: 10.1371/journal.pone.0112949

10. Andersen S., Jakobsen A., Laurberg P. Vitamin D Status in North Greenland Is Influenced by Diet and Season: Indicators of Dermal 25-Hydroxy Vitamin D Production North of the Arctic Circle. Br. J. Nutr., 2013, vol. 110, no. 1, pp. 50–57. DOI: 10.1017/S0007114512004709

11. Potolitsyna N.N., Boyko E.R. Vitamin Status in Residents of the European North of Russia and Its Correlation with Geographical Latitude. J. Med. Biol. Res., 2018, vol. 6, no. 4, pp. 376–386. DOI: 10.17238/issn2542-1298.2018.6.4.376

12. Nikiforova N.A., Karapetyan T.A., Dorshakova N.V. Osobennosti pitaniya zhiteley Severa (obzor literatury) [Dietary Habits of Northerners (Literature Review)]. Ekologiya cheloveka, 2018, no. 11, pp. 20–25. DOI: 10.33396/1728-0869-2018-11-20-25

13. Neville J.J., Palmieri T., Young A.R. Physical Determinants of Vitamin D Photosynthesis: A Review. JBMR Plus, 2021, vol. 5, no. 1. Art. no. e10460. DOI: 10.1002/jbm4.10460

14. Bais A.F., McKenzie R.L., Bernhard G., Aucamp P.J., Ilyas M., Madronich S., Tourpali K. Ozone Depletion and Climate Change: Impacts on UV Radiation. Photochem. Photobiol. Sci., 2015, vol. 14, no. 1, pp. 19–52. DOI: 10.1039/c4pp90032d

15. O’Neill C.M., Kazantzidis A., Ryan M.J., Barber N., Sempos C.T., Durazo-Arvizu R.A., Jorde R., Grimnes G., Eiriksdottir G., Gudnason V., Cotch M.F., Kiely M., Webb A.R., Cashman K.D. Seasonal Changes in Vitamin D-Effective UVB Availability in Europe and Associations with Population Serum 25-Hydroxyvitamin D. Nutrients, 2016, vol. 8, no. 9. Art. no. 533. DOI: 10.3390/nu8090533

16. Kozlov A.I., Vershubskaya G.G., Ryzhaenkov V.G. Syvorotochnyy 25-gidroksivitamin D u naseleniya Permskogo kraya [Serum 25-Hydroxyvitamin D in the Case of Population of Perm Region]. Meditsinskiy al’manakh, 2015, no. 4, pp. 219–222.

17. Oleröd G., Hultén L.M., Hammarsten O., Klingberg E. The Variation in Free 25-Hydroxy Vitamin D and Vitamin D-Binding Protein with Season and Vitamin D Status. Endocr. Connect., 2017, vol. 6, no. 2, pp. 111–120. DOI: 10.1530/EC-16-0078

18. Hansen L., Tjønneland A., Køster B., Brot C., Andersen R., Cohen A.S., Frederiksen K., Olsen A. Vitamin D Status and Seasonal Variation Among Danish Children and Adults: A Descriptive Study. Nutrients, 2018, vol. 10, no. 11. Art. no. 1801. DOI: 10.3390/nu10111801

19. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., Murad M.H., Weaver C.M. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 2011, vol. 96, no. 7, pp. 1911–1930. DOI: 10.1210/jc.2011-0385

20. Karonova T.L., Grineva E.N., Nikitina I.L., Tsvetkova E.V., Todieva A.M., Belyaeva O.D., Mikheeva E.P., Globa P.Yu., Andreeva A.T., Beletskaya I.S., Omel’chuk N.V., Fulonova L.S., Shlyakhto E.V. Uroven’ obespechennosti vitaminom D zhiteley severo-zapadnogo regiona RF (g. Sankt-Peterburg i g. Petrozavodsk) [The Prevalence of Vitamin D Deficiency in the Northwestern Region of the Russian Federation Among the Residents of St. Petersburg and Petrozavodsk]. Osteoporoz i osteopatii, 2013, no. 3, pp. 3–7.

21. Korchina T.Ya., Sukhareva A.S., Korchin V.I., Lapenko V.V. Obespechennost’ vitaminom D zhenshchin Tyumenskogo Severa [Serum Concentrations of Vitamin D in Women Living in the Tyumen North]. Ekologiya cheloveka, 2019, no. 5, pp. 31–36. DOI: 10.33396/1728-0869-2019-5-31-36

22. Ramnemark A., Norberg M., Pettersson-Kymmer U., Eliasson M. Adequate Vitamin D Levels in a Swedish Population Living Above Latitude 63°N: The 2009 Northern Sweden MONICA Study. Int. J. Circumpolar Health, 2015, vol. 74, no. 1. Art. no. 27963. DOI: 10.3402/ijch.v74.27963

23. Kozlov A.I., Vershubsky G.G. Systematic Review on 25-Hydroxyvitamin D Levels in Various Populations of the Russian North. Hum. Physiol., 2019, vol. 45, no. 5, pp. 565–575. DOI: 10.1134/S0362119719050062

24. Soininen S., Eloranta A.M., Lindi V., Venäläinen T., Zaproudina N., Mahonen A., Lakka T.A. Determinants of Serum 25-Hydroxyvitamin D Concentration in Finnish Children: The Physical Activity and Nutrition in Children (PANIC) Study. Br. J. Nutr., 2016, vol. 115, no. 6, pp. 1080–1091. DOI: 10.1017/S0007114515005292

25. Deleskog A., Piksasova O., Silveira A., Gertow K., Baldassarre D., Veglia F., Sennblad B., Strawbridge R.J., Larsson M., Leander K., Gigante B., Kauhanen J., Rauramaa R., Smit A.J., Mannarino E., Giral P., Gustafsson S.,
Östenson C.G., Humphries S.E., Tremoli E., de Faire U., Öhrvik J., Hamsten A. Serum 25-Hydroxyvitamin D Concentration in Subclinical Carotid Atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 2013, vol. 33, no. 11,
pp. 2633–2638. DOI: 10.1161/ATVBAHA.113.301593