UDC

616-092.6:616.72-003.8

DOI

10.37482/2687-1491-Z106

Authors

Elena A. Galashina* ORCID: https://orcid.org/0000-0001-6209-9120
Еkaterina V. Gladkova* ORCID: https://orcid.org/0000-0002-6207-2275
Vladimir Yu. Ul’yanov* ORCID: https://orcid.org/0000-0002-9466-8348
*V.I. Razumovsky Saratov State Medical University (Saratov, Russian Federation)
Corresponding author: Elena Galashina, address: ul. Chernyshevskogo 148, Saratov, 410002, Russian Federation; e-mail: koniuchienko1983@mail.ru

Abstract

The heterogeneity of osteoarthritis pathogenesis is determined by combinations of various parameters indicating the degree of joint degradation at the early stages of the disease. Subchondral bone metabolism markers in body fluids can indicate pathological degenerative processes in the articular tissue. The role of inflammatory factors in the development of articular damage in osteoarthritis is widely discussed in modern literature. In this regard, the purpose of the review was to analyse the data of Russian and foreign scientific literature on the pathogenetic role of subchondral remodelling and immune inflammation factors in early manifestations of primary osteoarthritis in larger joints. The scientific studies of 2015–2022 were retrieved from Medline, PubMed, Free Medical Journals, еLIBRARY, PubMed Central archives, as well as using Google and SpringerLink platforms, and Elsevier. The following keywords were searched for both in Russian and in English: primary osteoarthritis, early stages, subchondral remodelling, bone resorption markers, bone tissue formation markers, cytokines, interleukins, chemokines, anabolic growth factors, RANKL. The analysis revealed that bone resorption and formation markers, representing the tumour necrosis factor superfamily, a number of interleukins, chemokines, and anabolic growth factors can be involved in the pathogenesis of early manifestations of primary osteoarthritis in larger joints. The literature review suggests that subchondral bone remodelling is important in the pathogenesis of incipient osteoarthritis, whose main metabolic aspects can be objectified through biochemical markers identified in body fluids and joint tissues.

Keywords

primary osteoarthritis pathogenesis, early stages of primary osteoarthritis, subchondral remodelling, bone metabolism markers, cytokines, interleukins, chemokines, anabolic growth factors

References

1. Fazlova I.Kh., Usanova A.A., Guranova N.N., Radaykina O.G., Kosynkina D.D. Dostupnost’ vysokotekhnologichnoy meditsinskoy pomoshchi bol’nym s dekompensirovannymi formami deformiruyushchego osteoartroza krupnykh sustavov nizhnikh konechnostey [Availability of High-Tech Medical Care for Patients with Decompensated Forms of Osteoarthritis Deformans of Major Joints of Lower Limbs]. Sovremennye problemy nauki i obrazovaniya, 2020, no. 2. Art. no. 108. DOI: 10.17513/spno.29614
2. Ishtukov R.R., Minasov T.B., Yakupov R.R., Saubanov R.A., Ginoyan A.O., Garipov I.I., Tatlybaeva N.Z. An Analysis of Early Outcomes of Knee Osteoarthritis Surgical Treatment. Creative Surg. Oncol., 2018, vol. 8, no. 4, pp. 273–278 (in Russ.). DOI: 10.24060/2076-3093-2018-8-4-273-278
3. Alekseeva L.I., Telyshev K.A. Early Osteoarthritis: Development of Diagnostic Criteria. Sovremennaya revmatologiya, 2020, vol. 14, no. 3, pp. 140–145 (in Russ.). DOI: 10.14412/1996-7012-2020-3-140-145
4. Guilak F., Nims R.J., Dicks A., Wu C.-L., Meulenbelt I. Osteoarthritis as a Disease of the Cartilage Pericellular Matrix // Matrix Biol. 2018. № 71–72. P. 40–50. DOI: 10.1016/j.matbio.2018.05.008
5. Hopkins T., Wright K.T., Kuiper N.J., Roberts S., Jermin P., Gallacher P., Kuiper J.H. An in vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans // Cells. 2021. Vol. 10, № 8. Art. № 1903. DOI: 10.3390/cells10081903
6. Radin E.L., Paul I.L., Tolkoff M.J. Subchondral Bone Changes in Patients with Early Degenerative Joint Disease // Arthritis Rheumatol. 1970. Vol. 13, № 4. P. 400–405. DOI: 10.1002/art.1780130406
7. Messner K., Fahlgren A., Ross I., Andersson B. Simultaneous Changes in Bone Mineral Density and Articular Cartilage in a Rabbit Meniscectomy Model of Knee Osteoarthrosis // Osteoarthr. Cartil. 2000. Vol. 8, № 3. P. 197–206. DOI: 10.1053/joca.1999.0290
8. Luyten F.P., Bierma-Zeinstra S., Dell’Accio F., Kraus V.B., Nakata K., Sekiya I., Arden N.K., Lohmander L.S. Toward Classification Criteria for Early Osteoarthritis of the Knee // Semin. Arthritis Rheum. 2018. Vol. 47, № 4. P. 457–463. DOI: 10.1016/j.semarthrit.2017.08.006
9. Donell S. Subchondral Bone Remodelling in Osteoarthritis // EFORT Open Rev. 2019. Vol. 4, № 6. P. 221–229. DOI: 10.1302/2058-5241.4.180102
10. Zhu X., Chan Y.T., Yung P.S.H., Tuan R.S., Jiang Y. Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis // Front. Cell Dev. Biol. 2021. № 8. Art. № 607764. DOI: 10.3389/fcell.2020.607764
11. Kabalyk M.A. Biomarkery i uchastniki remodelirovaniya subkhondral’noy kosti pri osteoartroze [Biomarkers of Subchondral Bone Remodeling in Osteoarthritis]. Tikhookeanskiy meditsinskiy zhurnal, 2017, no. 1, pp. 36–41.
12. Gögebakan B., Izmirli M., Okuyan H.M., Ataç L. Biomarkers for Early Diagnosis of Osteoarthritis // Osteoarthritis. SM Group, 2016.
13. Карякина Е.В., Гладкова Е.В., Пучиньян Д.М. Значение факторов воспаления в ремоделировании суставного хряща и субхондральной кости в начальной стадии первичного остеоартроза // Цитокины и воспаление. 2018. Т. 17, № 1-4. С. 43–48.
14. Tsvinger S.M. Subklinicheskiy ateroskleroz u bol’nykh pervichnym osteoartrozom: zakonomernosti razvitiya i kriterii prognozirovaniya [Subclinical Atherosclerosis in Patients with Primary Osteoarthritis: Patterns of Development and Prognostic Criteria: Diss.]. Chita, 2021. 214 p.
15. Kalaitzoglou E., Griffin T.M., Humphrey M.B. Innate Immune Responses and Osteoarthritis // Curr. Rheumatol. Rep. 2017. Vol. 19, № 8. Art. № 45. DOI: 10.1007/s11926-017-0672-6
16. Nagy E.E., Nagy-Finna C., Popoviciu H., Kovács B. Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update // Clin. Interv. Aging. 2020. Vol. 15. P. 501–518. DOI: 10.2147/CIA.S242288
17. Ansari M.Y., Ahmad N., Haqqi T.M. Oxidative Stress and Inflammation in Osteoarthritis Pathogenesis: Role of Polyphenols // Biomed. Pharmacother. 2020. Vol. 129. Art. № 110452. DOI: 10.1016/j.biopha.2020.110452
18. Chow Y.Y., Chin K.-Y. The Role of Inflammation in the Pathogenesis of Osteoarthritis // Mediators Inflamm. 2020. Vol. 2020. Art. № 8293921. DOI: 10.1155/2020/8293921
19. Nguyen V.N., Huynh Q.T., Dang T.L., Nguyen V.T., Le H., Nguyen N.C. The Relationship Between Some Serum аnd Synovial Fluid Cytokines and Pain Level at the Early Stage of Knee Osteoarthritis // Nat. Volatiles Essent. Oils. 2021. Vol. 8, № 4. P. 11121–11134.
20. Zhu J., Ruan G., Cen H., Meng T., Zheng S., Wang Y., Li B., Zhu Z., Han W., Winzenberg T., Wluka A.E., Cicuttini F., Wang B., Ding C. Association of Serum Levels of Inflammatory Markers and Adipokines with Joint Symptoms and Structures in Participants with Knee Osteoarthritis // Rheumatology (Oxford). 2022. Vol. 61, № 3. P. 1044–1052. DOI: 10.1093/rheumatology/keab479
21. Gladkova E.V. Osobennosti immunnykh mekhanizmov regulyatsii remodelirovaniya khryashchevoy i kostnoy tkaney pri rannikh i pozdnikh proyavleniyakh pervichnogo i posttravmaticheskogo osteoartroza [Characteristics of Remodelling Regulatory Immune Mechanisms in Cartilage and Bone Tissues at Incipient and Late Presentations of Primary and Post-Traumatic Osteoarthrosis]. Rossiyskiy immunologicheskiy zhurnal, 2019, vol. 13, no. 2, pp. 748–750.
22. Hu N., Zhang J., Wang J., Wang P., Wang J., Qiang Y., Li Z., Wu T., Wang X., Wang Y., Li J., Liu X., Zhang J., Feng X., Ju B., Hao Z., Pu D., Lu X., Wang Q., He L. Biomarkers of Joint Metabolism and Bone Mineral Density Are Associated with Early Knee Osteoarthritis in Premenopausal Females // Clin. Rheumatol. 2022. Vol. 41, № 3. P. 819–829. DOI: 10.1007/s10067-021-05885-3
23. Klementeva V.I., Chernisheva T.V., Korochina K.V., Korochina I.E. Laboratory and Instrumental Study of Knee Joints in Patients with Early Gonarthrosis: Search for Relationship. Meditsinskiy akademicheskiy zhurnal, 2020, vol. 20, no. 3, pp. 99–106 (in Russ.).
 DOI: 10.17816/MAJ43455
24. Singh S., Kumar D., Raja R. Role of Urinary CTX I in Early Diagnosis of Osteoarthritis // MOJ Orthop. Rheumatol. 2015. Vol. 3, № 1. P. 229–232. DOI: 10.15406/mojor.2015.03.00077
25. Ren G., Krawetz R.J. Biochemical Markers for the Early Identification of Osteoarthritis: Systematic Review and Meta-Analysis // Mol. Diagn. 2018. Vol. 22, № 6. P. 671–682. DOI: 10.1007/s40291-018-0362-8
26. Omel’yanenko N.P., Slutskiy L.I. Soedinitel’naya tkan’ (gistofiziologiya i biokhimiya) [Connective Tissue (Histophysiology and Biochemistry)]. Vol. 2. Moscow, 2010. 600 p.
27. Eldin A.B., Mohamed E.S., EL Zahraa Hassan F. The Role of Sclerostin in Knee Osteoarthritis and Its Relation to Disease Progression // Egypt. J. Intern. Med. 2019. № 31. P. 958–964. DOI: 10.4103/ejim.ejim_108_19
28. Vasiliadis E.S., Evangelopoulos D.-S., Kaspiris A., Benetos I.S., Vlachos C., Pneumaticos S.G. The Role of Sclerostin in Bone Diseases // J. Clin. Med. 2022. Vol. 11, № 3. Art. № 806. DOI: 10.3390/jcm11030806
29. Min S., Shi T., Han X., Chen D., Xu Z., Shi D., Teng H., Jiang Q. Serum Levels of Leptin, Osteopontin, and Sclerostin in Patients with and Without Knee Osteoarthritis // Clin. Rheumatol. 2021. Vol. 40, № 1. P. 287–294. DOI: 10.1007/s10067-020-05150-z
30. Munjal A., Bapat S., Hubbard D., Hunter M., Kolhe R., Fulzele S. Advances in Molecular Biomarker for Early Diagnosis of Osteoarthritis // Biomol. Concepts. 2019. Vol. 10, № 1. P. 111–119. DOI: 10.1515/bmc-2019-0014
31. Molnar V., Matišić V., Kodvanj I., Bjelica R., Jeleč Ž., Hudetz D., Rod E., Čukelj F., Vrdoljak T., Vidović D., Starešinić M., Sabalić S., Dobričić B., Petrović T., Antičević D., Borić I., Košir R., Zmrzljak U.P., Primorac D. Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis // Int. J. Mol. Sci. 2021. Vol. 22, № 17. Art. № 9208. DOI: 10.3390/ijms22179208
32. Belova S.V., Gladkova E.V., Zubavlenko R.A., Romakina N.A., Ulyanov V.Yu. Local Changes in Connective Tissue and Systemic Evidences of Primary Osteoarthritis in Patients with Increased Risk of This Disease Development. Prev. Clin. Med., 2019, no. 2, pp. 68–73 (in Russ.).
33. Min S., Wang C., Lu W., Xu Z., Shi D., Chen D., Teng H., Jiang Q. Serum Levels of the Bone Turnover Markers Dickkopf-1, Osteoprotegerin, and TNF-α in Knee Osteoarthritis Patients // Clin. Rheumatol. 2017. Vol. 36, № 10. P. 2351–2358. DOI: 10.1007/s10067-017-3690-x
34. Mazurov V.I., Trofimova A.S., Trofimov E.A. Risk Factors and Some Aspects of the Osteoarthritis Pathogenesis. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova, 2016, vol. 8, no. 2, pp. 116–124 (in Russ.).
35. Nelin N.I., Khomutov V.P. Rol’ subkhondral’noy kosti pri osteoartroze i vozmozhnost’ optimizatsii reparatsii osteokhondrogennykh struktur elektricheskim polem elektreta [The Role of the Subchondral Bone in Osteoarthritis and the Possibility of Optimizing the Repair of Osteochondrogenic Structures by the Electric Field of the Electret]. Sovremennaya meditsina, 2021, no. 2, pp. 10–14.
36. Novakov V.B., Novakova O.N., Churnosov M.I. Faktory riska i molekulyarnye osnovy etiopatogeneza osteoartroza kolennogo sustava (obzor literatury) [Risk Factors and Molecular Entities of the Etiopathogenesis of the Knee Osteoarthritis (Literature Review)]. Geniy ortopedii, 2021, vol. 27, no. 1, pp. 112–120. DOI: 10.18019/1028-4427-2021-27-1-112-120
37. Aleksandrova Yu.N. O sisteme tsitokinov [On the Cytokines System]. Pediatriya. Zhurnal im. G.N. Speranskogo, 2007, vol. 86, no. 3, pp. 124–128.
38. Raymuev K.V., Ishchenko A.M., Malyshev M.E. Pro-Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova, 2018, vol. 10, no. 3, pp. 19–27.  DOI: 10.17816/mechnikov201810319-27
39. Hu W., Chen Y., Dou C., Dong S. Microenvironment in Subchondral Bone: Predominant Regulator for the Treatment of Osteoarthritis // Ann. Rheum. Dis. 2020. Vol. 80, № 4. P. 413–422. DOI: 10.1136/annrheumdis-2020-218089
40. Rajandran S.N., Ma C.A., Tan J.R., Liu J., Wong S.B.S., Leung Y.-Y. Exploring the Association of Innate Immunity Biomarkers with MRI Features in Both Early and Late Stages Osteoarthritis // Front. Med. (Lausanne). 2020. Vol. 7. Art. № 554669. DOI: 10.3389/fmed.2020.554669
41. Ni F., Zhang Y., Peng X., Li J. Correlation Between Osteoarthritis and Monocyte Chemotactic Protein-1 Expression: A Meta-Analysis // J. Orthop. Surg. Res. 2020. Vol. 15. Art. № 516. DOI: 10.1186/s13018-020-02045-2
42. van der Kraan P.M. Differential Role of Transforming Growth Factor-Beta in an Osteoarthritic or a Healthy Joint // J. Bone Metab. 2018. Vol. 25, № 2. P. 65–72. DOI: 10.11005/jbm.2018.25.2.65