UDC

[577.161.2+612.12]:618.2

DOI

10.37482/2687-1491-Z127

Authors

Tat’yana Yu. Astakhova*/** ORCID: http://orcid.org/0000-0002-8777-0686

*Khanty-Mansiysk State Medical Academy (Khanty-Mansiysk, Khanty-Mansi Autonomous Okrug – Yugra, Russian Federation)
**District Clinical Hospital (Khanty-Mansiysk, Khanty-Mansi Autonomous Okrug – Yugra, Russian Federation)

Corresponding author: Tat’yana Astakhova, address: ul. Kalinina 40, Khanty-Mansiysk, 628012, Khanty-Mansiyskiy аvtonomnyy оkrug – Yugra, Russian Federation; e-mail: atu-samba@mail.ru

Abstract

The purpose of this study was to assess vitamin D levels in pregnant women living in the Khanty-Mansi Autonomous Okrug – Yugra (Russia). Materials and methods. In the course of a cohort study during the period of 2019–2020, the level of 25(OH)D in the serum of 110 female residents of Khanty-Mansiysk was determined. The subjects were divided into two groups: nonpregnant (control) (n = 58) and pregnant (n = 52) women. Results. Both non-pregnant and pregnant (1st – 2nd trimesters) women living in the Khanty-Mansi Autonomous Okrug – Yugra showed low vitamin D levels: non-pregnant women, 21.3 ± 0.7 ng/ml; pregnant women in the 1st trimester, 20.6 ± 0.6 ng/ml; in the 2nd trimester, 19.2 ± 0.5 ng/ml; in the 3rd trimester, 18.4 ± 0.4 ng/ml. These levels are below the lower limit of physiologically optimal values. Pregnant women in the 2nd and 3rd trimesters had significantly lower concentrations of 25(OH)D compared to non-pregnant women. The hypovitaminosis we identified has a tendency to increase from the 1st to the 3rd trimester, as the mother’s vitamin D requirement steadily increases due to the intensive growth of the foetus’ bones. The average blood vitamin D level of pregnant women in the 3rd trimester was found to be 1.6 times lower than the lower limit of the reference range and 1.2 times lower than that in the control group. The results of the study indicate a need for systemic diagnostic, preventive and corrective measures that will eliminate vitamin D deficiency in women living in the Khanty-Mansi Autonomous Okrug – Yugra.

Keywords

pregnant women, pregnancy trimester, vitamin D deficiency, Khanty-Mansiysk

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