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Section: Biological sciences Download (pdf, 0.6MB )UDC612.015.3:577.16(470.11)DOI10.37482/2687-1491-Z156AuthorsAleksandra S. Vorontsova* ORCID: https://orcid.org/0000-0003-3643-0515Nadezda A. Vorobyeva* ORCID: https://orcid.org/0000-0001-6613-2485 Alyona I. Vorobyeva* ORCID: https://orcid.org/0000-0003-4817-6884 Elizaveta Yu. Mel’nichuk* ORCID: https://orcid.org/0000-0002-7000-5451 *Northern State Medical University (Arkhangelsk, Russian Federation) Corresponding author: Nadezda Vorobyeva, address: prosp. Troitskiy 51, Arkhangelsk, 163000, Russian Federation; e-mail: nadejdav0@gmail.com AbstractThe harsh climatic conditions of the subarctic regions of Russia, followed by lifestyle and nutritional changes, put a strain on the adaptive self-regulation mechanisms of newcomers. Acclimatization of foreign students coming to these regions, along with a high mental load and significant lifestyle modifications as well as alimentary and behavioural habits, can lead to homeostatic failure, in particular, folate metabolism disorder. It is known that both genetic (alleles determining the characteristics of folate and homocysteine metabolism) and phenotypic (nutritional and behavioural) factors play an important role in regulating folate metabolism. The purpose of this study was to analyse the folate status of ethnic Indians living in a subarctic region of Russia. Materials and methods. A prospective cross-sectional population-based study was conducted on a sample of ethnic Indians (n = 117) studying at Northern State Medical University in the city of Arkhangelsk. An analysis was performed of the relationship between folate levels and the duration of living in the subarctic region of Russia, body mass index, tobacco smoking, alcohol intake and nutritional status. The results of the study showed that folate levels in Indian students living in Arkhangelsk decreased significantly (from 10.0 [9.325; 13.65] ng/ml in the first year to 4.00 [4.00; 6.00] ng/ml in the sixth year of study; р < 0.001). This can be associated with changes in their diet (less vegetables), smoking and alcohol consumption, which are risk factors for impaired homocysteine metabolism and, as a consequence, for adverse vascular events. The significant folate deficiency in Indian students during their residence in subarctic conditions requires taking a number of measures aimed to prevent maladjustment disorders of folate metabolism in foreign students, which include quality of life, health and nutritional status controls as well as maintaining a healthy lifestyle, including giving up bad habits.Keywordsfolic acid, physiological adaptation, folate metabolism, ethnic Indians, subarctic region of Russia, tobacco smoking, nutritionReferences1. Bagnetova E.A., Malyukova T.I., Bolotov S.V. K voprosu ob adaptatsii organizma cheloveka k usloviyam zhizni v severnom regione [Adapting the Human Body to Living Conditions in the Northern Region]. Uspekhi sovremennogo estestvoznaniya, 2021, no. 4, pp. 111–116. DOI: 10.17513/use.376162. Ignat’eva S.N., Kubasov R.V. Metabolicheskie adaptatsionnye vozmozhnosti organizma k obucheniyu studentov meditsinskogo vuza na Evropeyskom Severe [Students’ Metabolic Adaptation Resources to Studying at a Medical University in the European North]. Vestnik RAMN, 2014, no. 11–12, pp. 84–88. PMID: 25971132; DOI: 10.15690/vramn.v69i11-12.1188 3. Kir’yanov A.B., Kozhevnikova I.S., Anikina N.Yu., Gribanov A.V. Osobennosti mozgovoy aktivnosti u indiyskikh studentov, nachavshikh obuchenie v arkticheskom vuze [Specifics of Brain Activity in Indian Students in the Arctic University]. Mezhdunarodnyy nauchno-issledovatel’skiy zhurnal, 2022, no. 9. Art. no. 10. DOI: 10.23670/IRJ.2022.123.63 4. Govorukhina A.A., Mal’kov O.A., Novoselova A.A. Sostoyanie sosudov kak odin iz kriteriev adaptatsii organizma v usloviyakh Severa [Vascular Condition as One of the Criteria of Adaptation in the North]. Elektronnyy nauchno-obrazovatel’nyy vestnik “Zdorov’e i obrazovanie v XXI veke”, 2016, vol. 18, no. 11, pp. 55–59. Available at: https://cyberleninka.ru/article/n/sostoyanie-sosudov-kak-odin-iz-kriteriev-adaptatsii-organizma-v-us... viewer (accessed: 22 August 2023). 5. Vorobyeva N.A., Vorobyeva A.I., Yuryev N.A., Nemanova S.B. To the Question of Diagnoses of Endothelial Dysfunction Under the Conditions of the Transported Flight in the Arctic. Ekologiya cheloveka, 2018, vol. 25, no. 1, pp. 53–59. DOI: 10.33396/1728-0869-2018-1-53-59 6. Pristrom A.M. Rol’ folatov v serdechno-sosudistoy profilaktike: sovremennoe sostoyanie problemy [The Role of Folate in Cardiovascular Prophylaxis: Current Status of the Problem]. Mezhdunarodnye obzory: klinicheskaya praktika i zdorov’e, 2020, no. 1, pp. 62–77. 7. Healthy Diet. World Health Organization. Available at: https://www.who.int/ru/news-room/fact-sheets/detail/healthy-diet (accessed: 20 March 2023) (in Russ.). 8. Lebedeva A.Yu., Mikhaylova K.V. Gipergomotsisteinemiya: sovremennyy vzglyad na problemu [Hyperhomocysteinemia: A Modern View of the Problem]. Rossiyskiy kardiologicheskiy zhurnal, 2006, no. S, pp. 149–157. 9. Belova N.I., Lavrinov P.A., Vorobyeva N.A. Novye markery riska serdechno-sosudistykh zabolevaniy v populyatsii nentsev Nenetskogo avtonomnogo okruga [New Risk Markers for Cardiovascular Pathology in the Nenets Population of the Nenets Autonomous Area]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Medikobiologicheskie nauki, 2014, no. 2, pp. 12–20. 10. Martynov A.S., Vinogradov V.G. Severnye osobennosti pitaniya [Northern Nutrition]. Okruzhayushchaya sreda i zdorov’e naseleniya Rossii: web-atlas [Environment and Health of the Population of Russia: Web-Atlas]. Available at: http://www.sci.aha.ru/ATL/ra00.htm (accessed: 22 August 2023). 11. Nikiforova N.A., Karapetyan T.A., Dorshakova N.V. Osobennosti pitaniya zhiteley Severa (obzor literatury) [Dietary Habits of Northerners (Literature Review)]. Ekologiya cheloveka, 2018, no. 11, pp. 20–25. 12. Cirillo M., Argento F.R., Attanasio M., Becatti M., Ladisa I., Fiorillo C., Coccia M.E., Fatini C. Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder. Biomedicines, 2023, vol. 11, no. 2. Art. no. 450. DOI: 10.3390/biomedicines11020450 13. Podzolkov V.I., Bragina A.E., Druzhinina N.A. Vzaimosvyaz’ kureniya i urovnya markerov endotelial’noy disfunktsii u bol’nykh gipertonicheskoy bolezn’yu [Relation of Smoking and Endothelial Dysfunction Markers in Systemic Hypertension]. Kardiovaskulyarnaya terapiya i profilaktika, 2018, vol. 17, no. 5, pp. 11–16. DOI: 10.15829/1728-8800-2018-5-11-16 14. Hamid A., Wani N.A., Kaur J. New Perspectives on Folate Transport in Relation to Alcoholism-Induced Folate Malabsorption – Association with Epigenome Stability and Cancer Development. FEBS J., 2009, vol. 276, no. 8, pp. 2175–2191. DOI: 10.1111/j.1742-4658.2009.06959.x 15. Liu A.S.L.W., Neves F.J., Pinto J., Amorim P.M.S., Bonilha A.C., Mapurunga M., Moscardi A.V.S., Demarzo M., Guerra-Shinohara E.M., D’Almeida V., Ramos L.R., Andreoni S., Tomita L.Y. Reduced Circulating Folate Among Older Adults Caused by Continuous Work: Nested Cross-Sectional Study Conducted in a Country with Folic Acid Fortification Program. Nutr. Res., 2022, vol. 108, pp. 43–52. DOI: 10.1016/j.nutres.2022.10.008 16. Ortega R.M., Jiménez Ortega A.I., Martínez García R.M., Lorenzo-Mora A.M., Lozano-Estevan M.D.C. Problemática nutricional en fumadores y fumadores pasivos. Nutr. Hosp., 2021, vol. 38, no. S2, pp. 31–34. DOI: 10.20960/nh.03794 17. Zhilyaeva T.V., Kasyanov E.D., Pyatoikina A.S., Blagonravova A.S., Mazo G.E. The Association of Serum Folate Levels with Schizophrenia Symptoms. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, vol. 122, no. 8, pp. 128–135 (in Russ.). DOI: 10.17116/jnevro2022122081128 |
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