UDC

616-092.9(599.323.4+616.24-005.98):615.8

DOI

10.37482/2687-1491-Z172

Authors

Svetlana V. Kopylova* ORCID: https://orcid.org/0000-0002-5527-9075
Edner Jacquet* ORCID: https://orcid.org/0000-0002-2215-2078

*National Research Lobachevsky State University of Nizhny Novgorod
(Nizhny Novgorod, Russian Federation)

Corresponding author: Svetlana Kopylova, address: prosp. Gagarina 23, Nizhny Novgorod, 603950, Russian Federation; e-mail: gorelaya@mail.ru

Abstract

In pulmonary oedema, the accumulation of tissue fluid in the interstitial spaces of the lungs as well as in the cavities of the alveoli prevents the respiratory system from performing the gas exchange function. The ineffectiveness of various therapeutic approaches proposed to combat SARS-CoV-2 justifies the search for new therapeutic agents. Extremely high frequency (EHF) therapy could be one of the alternative treatment methods. The purpose of this article was to evaluate the immunometabolic status of rats in mono-EHF therapy of pulmonary oedema. Materials and methods. The paper evaluated the concentration of circulating immune complexes in the blood serum and the activity of lactate dehydrogenase in the lung tissue at experimental pulmonary oedema and a course of EHF therapy. The study involved 60 rats divided into 3 groups (intact, control and experimental). In the control and experimental groups, pulmonary oedema was simulated by intraperitoneal administration of adrenaline hydrochloride. A 10-day EHF therapy course was given to the experimental group using the CEMTECH device (40−43 GHz, Russia) by targeting three acupuncture points. Results. Pulmonary oedema was shown to increase the level of circulating immune complexes in the blood and the activity of lactate dehydrogenase in the lung tissue. Exposure to EHF radiation restored the normal values of these parameters. EHF therapy proved to be a promising treatment and rehabilitation method for pulmonary oedema. The selected markers for assessing the immunometabolic status could serve as an addition to the traditional methods of diagnosing this pathology, including in experimental conditions.

Keywords

circulating immune complexes, lactate dehydrogenase, EHF radiation, pulmonary oedema, immunometabolic status, SARS-CoV-2

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