UDC

611.018.5+612.12(985)(479)(045)

DOI

10.37482/2687-1491-Z178

Authors

Boris А. Shengof* ORCID: https://orcid.org/0000-0002-3776-1474
Fatima A. Bichkaeva* ORCID: https://orcid.org/0000-0003-2970-4469
Ekaterina V. Nesterova* ORCID: https://orcid.org/0000-0001-8467-2514

*N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences
(Arkhangelsk, Russian Federation)

Corresponding author: Boris Shengof, address: prosp. Lomonosova 249, Arkhangelsk, 163001, Russian Federation; e-mail: b-shengof@yandex.ru

Abstract

Disordered endogenous synthesis as well as changes in the quantity and qualitative composition of fatty acids in the diet can become pathogenetic factors in a number of metabolic diseases. The purpose of this article was a comparative analysis of the content of monounsaturated fatty acids (palmitoleic, elaidic, oleic, gondoic, erucic and nervonic) in the peripheral blood of residents of different climatic regions. Materials and methods. The research was conducted between 2008 and 2018 and involved 697 subjects aged 22 to 60 years. Depending on the region of permanent residence, all the participants were divided into three groups: 1) residents of the Arctic region (AR); 2) people living in the circumpolar region (CR); 3) residents of the South Caucasus (SC). The level of monounsaturated fatty acids (MUFAs) in the blood serum was evaluated using gas-liquid chromatography. Results. The analysis of the data obtained demonstrates that the total concentration of MUFAs in the peripheral blood of AR and CR residents is statistically significantly lower compared to the people of SC. In particular, northerners showed lower concentrations of palmitoleic, oleic and gondoic acids. Moreover, in the AR group, the level of elaidic acid was higher than in the SC group, while the concentration of erucic acid was lower than in the CR and SC groups. In terms of nervonic acid, a statistically significantly lower content was detected in SC residents compared to the CR group, while the probability of differences between SC and AR residents was at the trend level. Thus, extreme factors of the North cause adaptive rearrangements in fat metabolism at the level of major and minor fatty acid components. At the same time, the changes are closely linked with the structure of nutrition and can be attributed to an unbalanced diet.

Keywords

monounsaturated fatty acids, palmitoleic acid, elaidic acid, oleic acid, Arctic region, subpolar region, South Caucasus

References

1. Novikov V.S., Soroko S.I. Fiziologicheskie osnovy zhiznedeyatel’nosti cheloveka v ekstremal’nykh usloviyakh [Physiological Bases of Human Life in Extreme Conditions]. St. Petersburg, 2017. 476 p.
2. Petrova P.G. Ekologo-fiziologicheskie aspekty adaptatsii cheloveka k usloviyam Severa [Ecological and Physiological Aspects of Human Adaptation to the Conditions of the North]. Vestnik Severo-Vostochnogo federal’nogo universiteta im. M.K. Ammosova. Ser.: Meditsinskie nauki, 2019, no. 2, pp. 29–38.
3. Korchin V.I., Korchina T.Ya., Ternikova E.M., Bikbulatova L.N., Lapenko V.V. Influence of Climatic and Geographical Factors of the Yamalo-Nenets Autonomous Okrug on the Health of Its Population (Review). J. Med. Biol. Res., 2021, vol. 9, no. 1, pp. 77–88. https://doi.org/10.37482/2687-1491-Z046
4. Shchetinina S.Yu., Yudicheva N.V. Vliyanie geomagnitnoy aktivnosti na sostoyanie zdorov’ya cheloveka [The Influence of Geomagnetic Activity on Human Health Condition]. Mezhdunarodnyy zhurnal gumanitarnykh i estestvennykh nauk, 2021, no. 5-1, pp. 167–169. https://doi.org/10.24412/2500-1000-2021-5-1-167-169
5. Panin L.E. Gomeostaz i problemy pripolyarnoy meditsiny (metodologicheskie aspekty adaptatsii) [Homeostasis and Problems of Circumpolar Health (Methodological Aspects of Adaptation)]. Byulleten’ Sibirskogo otdeleniya RAMN, 2010, vol. 30, no. 3, pp. 6–11.
6. Panin L.E. Energeticheskie aspekty adaptatsii [Energy Aspects of Adaptation]. Leningrad, 1978. 192 p.
7. Kaznacheev V.P. Sovremennye aspekty adaptatsii [Modern Aspects of Adaptation]. Novosibirsk, 1980. 192 p.
8. Boyko E.R. Fiziologo-biokhimicheskie osnovy zhiznedeyatel’nosti cheloveka na Severe [Physiological and Biochemical Bases of Human Life in the North]. Yekaterinburg, 2005. 190 p.
9. Schwingshackl L., Strasser B., Hoffmann G. Effects of Monounsaturated Fatty Acids on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Ann. Nutr. Metab., 2011, vol. 59, no. 2-4, pp. 176–186. https://doi.org/10.1159/000334071
10. Hulbert A.J., Turner N., Storlien L.H., Else P.L. Dietary Fats and Membrane Function: Implications for Metabolism and Disease. Biol. Rev., 2005, vol. 80, no. 1, pp. 155–169. https://doi.org/10.1017/S1464793104006578
11. Bichkaev A.A., Bichkaeva F.A., Volkova N.I., Shengof B.A. Vozrastnye osobennosti mononenasyshchennykh zhirnykh kislot u zhiteley Severa [Age-Related Peculiarities of Monounsaturated Fatty Acids in Residents of the North]. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki, 2014, no. 3, pp. 157–159.
12. Bichkaeva F.A., Volkova N.I., Lobanov A.A., Kochkin R.A. Adaptive Aging Changes of Omega-7 Monounsaturated Fatty Acid and Parameters of Carbohydrate Metabolism in Blood of Inhabitants of the North of Russia. Vestnik Ural’skoy meditsinskoy akademicheskoy nauki, 2018, vol. 15, no. 2, pp. 151–161 (in Russ.). https://doi.org/10.22138/2500-0918-2018-15-2-151-161
13. Report “On the State and Protection of the Environment of the Nenets Autonomous Area in 2016”. Naryan-Mar, 2017. Available at: http://cpoos-nao.ru/docs/doklad_o_sostojanii_okruzhajushhej_sredy_v_2016_g..docx (accessed: 10 May 2023) (in Russ.).
14. General Characteristics of the Climate of the Arkhangelsk Region and Nenets Autonomous Area. Northern Department of Hydrometeorology and Environmental Monitoring. Available at: http://www.sevmeteo.ru/files/arh-nao.pdf (accessed: 10 May 2023) (in Russ.).
15. Badov A.D., Dzhioeva V.D. Prirodnye usloviya i resursy kak vazhneyshiy faktor ustoychivogo sotsial’noekonomicheskogo razvitiya Yuzhnoy Osetii [Natural Conditions and Resources as an Important Factor of Sustainable Socio-Economic Development of South Ossetia]. Vestnik Adygeyskogo gosudarstvennogo universiteta. Ser. 4: Estestvenno-matematicheskie i tekhnicheskie nauki, 2017, no. 1, pp. 91–94.
16. Bichkaeva F.A., Baranova N.F., Vlasova O.S., Nesterova E.V., Bichkaev A.A., Shengof B.A., Tretyakova T.V. Method for Measuring Mass Concentration of Methyl Esters of Fatty Acids in Biological Media by Gas-Liquid Chromatography Method. Patent RU2758932C1, 2021. 31 p. (in Russ.).
17. Rozhkova T.A., Aripovsky A.V., Yarovaya E.B., Kaminnaya V.I., Kukharchuk V.V., Titov V.N. The Individual Fatty Acids of Blood Plasma: Biological Role of Substrates, Parameters of Quantity and Quality, Diagnostic of Atherosclerosis and Atheromotosis. Klinicheskaya laboratornaya diagnostika, 2017, vol. 62, no. 11, pp. 655–665 (in Russ.).
18. Kaminnaya V.I., Rozhkova T.A., Solov’eva E.Yu., Konovalova G.G., Titov V.N., Yarovaya E.B., Chirkovskaya M.V. Vklad individual’nykh zhirnykh kislot plazmy krovi v formirovanie giperlipidemiy aterogennogo geneza u patsientov s serdechno-sosudistymi zabolevaniyami [Contribution of Individual Fatty Acids of Blood Plasma to the Formation of Atherogenic Hyperlipidemia in Patients with Cardiovascular Diseases]. World Science: Problems and Innovations. Penza, 2019, pp. 234–238.
19. Medvedev O.S., Medvedeva Z.O. Transizomery zhirnykh kislot kak opasnyy komponent nezdorovogo pitaniya [Trans-Isomer Fatty Acids as a Dangerous Component of Unhealthy Foods]. Voprosy dietologii, 2015, vol. 5, no. 2, pp. 54–63.
20. Hirata Y., Nada Y., Yamada Y., Toyama T., Fukunaga K., Hwang G.W., Noguchi T., Matsuzawa A. Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X7-ROS-ASK1-p38 Axis in Microglial Cell Lines. Biol. Pharm. Bull., 2020, vol. 43, no. 10, pp. 1562–1569. https://doi.org/10.1248/bpb.b20-00409
21. Titov V.N., Dygai A.M., Kotlovskiy M.Yu., Kurdoyak Ye.V., Yakimenko A.V., Yakimovich I.Yu., Aksyutina N.V., Kotlovskiy Yu.V. Palmitic and Oleic Acids and Their Role in Pathogenesis of Atherosclerosis. Bull. Sib. Med., 2014, vol. 13, no. 5, pp. 149–159 (in Russ.). https://doi.org/10.20538/1682-0363-2014-5-149-159
22. Titov V.N. Sintez nasyshchennykh, monoenovykh, nenasyshchennykh i polienovykh zhirnykh kislot v filogeneze. Evolyutsionnye aspekty ateroskleroza [Synthesis of Saturated, Monoenic, Unsaturated and Polyenic Fatty Acids. Evolutionary Aspects of Atherosclerosis]. Uspekhi sovremennoy biologii, 2012, vol. 132, no. 2, pp. 181–199.
23. Prakhova T.Ya., Zelenina O.N. Kachestvennaya kharakteristika maslosemyan ozimogo ryzhika [Qualitative Characteristics of Winter Camelina Oilseeds]. Niva Povolzh’ya, 2009, no. 3, pp. 84–87.
24. Vetter W., Darwisch V., Lehnert K. Erucic Acid in Brassicaceae and Salmon – аn Evaluation of the New Proposed Limits of Erucic Acid in Food. NFS J., 2020, vol. 19, pp. 9–15. https://doi.org/10.1016/j.nfs.2020.03.002
25. Bremer J., Norum K.R. Metabolism of Very Long-Chain Monounsaturated Fatty Acids (22:1) and the Adaptation to Their Presence in the Diet. J. Lipid Res., 1982, vol. 23, no. 2, pp. 243–256. https://doi.org/10.1016/S0022-2275(20)38153-0
26. Sassa T., Kihara A. Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology. Biomol. Ther. (Seoul), 2014, vol. 22, no. 2, pp. 83–92. https://doi.org/10.4062/biomolther.2014.017
27. Lewkowicz N., Piątek P., Namiecińska M., Domowicz M., Bonikowski R., Szemraj J., Przygodzka P., Stasiołek M., Lewkowicz P. Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes. Cells, 2019, vol. 8, no. 8. Art. no. 786. https://doi.org/10.3390/cells8080786