UDC

612.123:616.153.915(985)

DOI

10.37482/2687-1491-Z222

Authors

Veronika A. Solovyova* ORCID: https://orcid.org/0000-0002-2954-8040
Ulker G. Guseynova* ORCID: https://orcid.org/0000-0002-6932-0446
Nataliya V. Solovieva* ORCID: https://orcid.org/0000-0002-0664-4224
Nikolay S. Ishekov* ORCID: https://orcid.org/0000-0002-1537-035X
Andrey G. Soloviev* ORCID: https://orcid.org/0000-0002-0350-1359
Lyubov I. Gubareva** ORCID: https://orcid.org/0000-0001-6387-2031
*Northern State Medical University (Arkhangelsk, Russia)
**North Caucasian Federal University (Stavropol, Russia)
Corresponding author: Veronika Solovyova, address: prosp. Troitskiy 51, Arkhangelsk, 163000, Russia; e-mail: taurus221@yandex.ru

Abstract

This article aimed to systematize data on lipid metabolism parameters in various population groups of the Arctic region in the historical aspect and in modern conditions. The materials were selected using international (Web of Science and Scopus) and Russian (Cyberleninka and eLIBRARY.RU) databases. The following keywords were searched for: Arctic, lipid metabolism, risk factors. The sample included 34 works on the changes in lipid metabolism in the inhabitants of the Arctic region published between 1979 and 2023. It has been shown that the indigenous population is more likely to have a favourable blood lipid profile, with a low content of lowdensity lipoproteins (LDL) and triglycerides (TG), but high content of high-density lipoproteins (HDL). In zerogeneration newcomers, when their adaptation is disrupted, atherogenic dyslipidaemia often develops, while in first- and second-generation newcomers, lipid metabolism occupies an intermediate position, approaching the parameters of the indigenous population. Along with climatic and geographical conditions, socio-economic factors (dietary changes, smoking and alcohol abuse) affect the human body, leading to atherogenic dyslipidaemia, which is the basis of cardiovascular diseases. An important role in assessing lipid metabolism disorders in the Arctic is played by determining more reliable markers of atherosclerosis, namely, the content of apolipoproteins (apoA and apoB) and fatty acids consumed. The indigenous inhabitants of the North typically have a protein- and fatrich diet characterized by increased levels of omega-3 and decreased levels of omega-6 polyunsaturated fatty acids (PUFAs). However, in recent decades, low levels of both omega-3 and omega-6 PUFAs have become more common. For early detection of signs of lipid metabolism disorders, we need to study not only the “traditional” parameters, i.e. total cholesterol, TG, LDL and HDL, but also apoA-I and apoB as well as omega-6 and omega-3 PUFAs in order to develop science-based diagnostic methods, differentiated wellness programmes and therapeutic measures.

For citation: Solovyova V.A., Guseynova U.K., Solovieva N.V., Ishekov N.S., Soloviev A.G., Gubareva L.I. Physiological Aspects of Lipid Metabolism in the Arctic Zone of the Russian Federation (Review). Journal of Medical and Biological Research, 2024, vol. 12, no. 4, pp. 548–558. DOI: 10.37482/2687-1491-Z222

Keywords

lipid metabolism, inhabitants of the Arctic, non-indigenous population of the North, zero-generation newcomers, first- and second-generation newcomers, adaptation to the North, cardiovascular disease risk factors

References

1. Boyko E.R. (ed.). Adaptatsiya cheloveka k ekologicheskim i sotsial’nym usloviyam Severa [Human Adaptation to Environmental and Social Conditions in the North]. Syktyvkar, 2012. 442 p.
2. Sofronova S.I., Romanova A.N. Arterial’naya gipertenziya i nekotorye faktory riska ee razvitiya u korennogo i prishlogo naseleniya Yakutii [Arterial Hypertension and Some Risk Factors for Its Development in the Indigenous and Non-Indigenous Population of Yakutia]. Vestnik Severo-Vostochnogo federal’nogo universiteta im. M.K. Ammosova. Ser.: Meditsinskie nauki, 2023, no. 3, pp. 39–44. https://doi.org/10.25587/SVFU.2023.58.28.005
3. Sevost’yanova E.V. Osobennosti lipidnogo i uglevodnogo metabolizma cheloveka na Severe (literaturnyy obzor) [Some Features of Human Lipid and Carbohydrate Metabolism in the North (Literature Review)]. Byulleten’ sibirskoy meditsiny, 2013, vol. 12, no. 1, pp. 93–100.
4. Polyakov L.M., Rozumenko A.A., Osipova L.P., Kunitsyn V.G., Gol’tsova T.V. Lipidnyy spektr syvorotki krovi u predstaviteley korennogo i prishlogo naseleniya Yamalo-Nenetskogo avtonomnogo okruga [Serum Lipid Spectrum of Indigenous and Alien Population of Yamalo-Nenets Autonomous Okrug]. Sibirskiy nauchnyy meditsinskiy zhurnal, 2015, vol. 35, no. 6, pp. 66–69.
5. Alekseeva S.N., Antipina U.D., Ptitsyna S.P., Sobakin Yu.V., Betyunskaya E.P., Protod’yakonov S.V. Sravnitel’naya kharakteristika lipidnogo i gormonal’nogo statusa u zhiteley raznykh rayonov Respubliki Sakha (Yakutiya) [Comparative Characteristics of Lipid and Hormonal Status in Residents of Different Districts of the Sakha Republic (Yakutia)]. Vestnik Severo-Vostochnogo federal’nogo universiteta im. M.K. Ammosova. Ser.: Meditsinskie nauki, 2020, no. 4, pp. 5–12.
6. Averyanova I.V., Maksimov А.L., Borisenko N.S. Osobennosti lipidnogo i uglevodnogo obmena yunoshey – aborigenov i ukorenennykh evropeoidov Magadanskoy oblasti [Lipid and Carbohydrate Metabolism in Indigenous and Caucasian Young Males Living in the Magadan Region]. Vestnik Severnogo (Arkticheskogo) federal’nogo universiteta. Ser.: Mediko-biologicheskie nauki, 2016, no. 2, pp. 5–15. https://doi.org/10.17238/issn2308-3174.2016.2.5
7. Panin L.E. Energeticheskie aspekty adaptatsii [Energy Aspects of Adaptation]. Leningrad, 1978. 191 p.
8. Agadzhanyan N.A., Zhvavyy N.F., Anan’ev V.N. Adaptatsiya cheloveka k usloviyam Kraynego Severa: ekologofiziologicheskie mekhanizmy [Human Adaptation to the Conditions of the Far North: Ecological and Physiological Mechanisms]. Moscow, 1998. 240 p.
9. Krivoshapkina Z.N., Mironova G.E., Semyonova E.I., Olesova L.D. Biochemical Spectrum of Blood Serum as Indicator of Yakutia Residents Adaptedness to Northern Conditions. Hum. Ecol., 2015, no. 11, pp. 19–24 (in Russ.).
10. Panin L.E. Fundamental’nye problemy pripolyarnoy i arkticheskoy meditsiny [Fundamental Problems of the Circumpolar and the Arctic Medicine]. Byulleten’ Sibirskogo otdeleniya RAMN, 2013, vol. 33, no. 6, pp. 5–10.
11. Averyanova I.V., Maximov A.L. Main Characteristics of Lipid and Carbohydrate Metabolism Observed in Young Males with Different Somatotypes of Northeast Russia. Hum. Ecol., 2017, no. 12, pp. 40–44 (in Russ.). https://doi.org/10.33396/1728-0869-2017-12-40-44
12. Vorontsova E.V., Vorontsov A.L. Sostoyanie okruzhayushchey sredy i zdorov’e cheloveka v Arkticheskoy zone: meditsinskiy i sotsial’no-pravovoy aspekt [Environmental State and Human Health in the Arctic Zone: Medical аnd Socio-Legal Aspect]. Yakutskiy meditsinskiy zhurnal, 2019, no. 3, pp. 85–90. https://doi.org/10.25789/YMJ.2019.67.24
13. Shajmardanov A.R., Litovchenko O.G. Comparative Analysis of the Severity of Oxidative Stress in the Indigenous and Non-Indigenous Population of the Yamalo-Nenets Autonomous Okrug. Mod. Iss. Biomed., 2023, vol. 7, no. 4. Art. no. 23 (in Russ.).
14. Khasnulin V.I., Gevorgyan M.M., Bakhtina I.A. Osobennosti lipidnogo obmena u prishlykh zhiteley Severa, bol’nykh arterial’noy gipertenziey [Lipid Metabolism Characteristics at the Alien Inhabitants of the North with Arterial Hypertension]. Mir nauki, kul’tury, obrazovaniya, 2011, no. 4-2, pp. 280–283.
15. Aver’yanova I.V., Maksimov A.L. Sostoyanie lipidnogo i uglevodnogo obmena u studentov-aborigenov i evropeoidov s razlichnymi srokami prozhivaniya na territorii Magadanskoy oblasti [Lipid and Carbohydrate Metabolism Observed in Aboriginal and European Students Having Different Terms of Residing in Territory of Magadan Region]. Ekologiya cheloveka, 2015, no. 9, pp. 44–49.
16. Kadomtseva L.V., Zufarova A.A., Polikarpova N.V. Apolipoproteiny B i A1 – kak markery riska razvitiya serdechno-sosudistykh zabolevaniy [Apolipoproteins B аnd A1 as Markers of Cardiovascular Diseases]. Vestnik ekstrennoy meditsiny, 2019, vol. 12, no. 5, pp. 67–70.
17. Carnevale Schianca G.P., Pedrazzoli R., Onolfo S., Colli E., Cornetti E., Bergamasco L., Fra G.P., Bartoli E. ApoB/ApoA-I Ratio Is Better Than LDL-C in Detecting Cardiovascular Risk. Nutr. Metab. Cardiovasc. Dis., 2011, vol. 21, no. 6, pp. 406–411. https://doi.org/10.1016/j.numecd.2009.11.002
18. Anderson T.J., Grégoire J., Hegele R.A., Couture P., Mancini G.B.J., McPherson R., Francis G.A., Poirier P., Lau D.C., Grover S., Genest J. Jr., Carpentier A.C., Dufour R., Gupta M., Ward R., Leiter L.A., Lonn E., Ng D.S., Pearson G.J., Yates G.M., Stone J.A., Ur E. 2012 Update of the Canadian Cardiovascular Society Guidelines for the Diagnosis and Treatment of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult. Can. J. Cardiol., 2013, vol. 29, no. 2, pp. 151–167. https://doi.org/10.1016/j.cjca.2012.11.032
19. Bichkaeva F.A., Kokoev T.I., Dzhioeva Ts.G., Dzhabieva Z.A., Volkova N.I., Tret’yakova T.V., Vlasova O.S. Soderzhanie v syvorotke krovi apolipoproteinov A, B i parametry obmena lipidov u zhiteley pripolyarnykh regionov Severa i yuzhnykh regionov Kavkaza [Serum Levels of Apolipoproteins A and B and Lipid Metabolism Parameters in Residents of the Polar Regions of the North and Southern Regions of the Caucasus]. Klinicheskaya laboratornaya diagnostika, 2013, no. 1, pp. 25–27.
20. Kaneva A.M., Potolitsyna N.N., Lyudinina A.Yu., Alisultanova N.Zh., Boyko E.R. Nizkoe soderzhanie apolipoproteina E kak faktor riska povysheniya sootnosheniya apolipoprotein B/A-1 u zdorovykh muzhchin s normolipidemiey [The Low Content of Apolipoprotein E as a Risk Factor of Increasing of Ratio Apolipoprotein B/A-1 in Healthy Males with Normal Lipemia]. Klinicheskaya laboratornaya diagnostika, 2014, vol. 59, no. 12, pp. 32–36.
21. Istomin A.V., Fedina I.N., Shkurikhina S.V., Kutakova N.S. Food and the North: Hygienic Problems of the Arctic Zone of Russia (the Review of the Literature). Gigiena i sanitariya, 2018, vol. 97, no. 6, pp. 557–563 (in Russ.). https://doi.org/10.18821/0016-9900-2018-97-6-557-563
22. Caron J.P., Gandy J.C., Brown J.L., Sordillo L.M. Omega-3 Fatty Acids and Docosahexaenoic Acid Oxymetabolites Modulate the Inflammatory Response of Equine Recombinant Interleukin 1β-Stimulated Equine Synoviocytes. Prostaglandins Other Lipid Mediat., 2019, vol. 142, pp. 1–8. https://doi.org/10.1016/j.prostaglandins.2019.02.007
23. Wang L., Manson J.E., Rautiainen S., Gaziano J.M., Buring J.E., Tsai M.Y., Sesso H.D. A Prospective Study of Erythrocyte Polyunsaturated Fatty Acid, Weight Gain, and Risk of Becoming Overweight or Obese in Middle-Aged and Older Women. Eur. J. Clin. Nutr., 2016, vol. 55, no. 2, pp. 687–697. https://doi.org/10.1007/s00394-015-0889-y
24. Simopoulos A.P. An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity. Nutrients, 2016, vol. 8, no. 3. Art. no. 128. https://doi.org/10.3390/nu8030128
25. Galstyan D.S., Bichkaeva F.A., Baranova N.F. Concentrations of Polyunsaturated Fatty Acids by Body Mass Index Among Arctic Residents. Hum. Ecol., 2020, no. 9, pp. 4–10 (in Russ.). https://doi.org/10.33396/1728-0869-2020-9-4-10
26. Tretyakova T.V., Vlasova O.S., Baranova N.F. Comparative Analysis of Parameters of Lipid and Carbohydrate Metabolism in Aboriginal and Nonaboriginal Young People in the Arctic Region. J. Ural Med. Acad. Sci., 2018, vol. 15, no. 2, pp. 229–238 (in Russ.). https://doi.org/10.22138/2500-0918-2018-15-2-229-238
27. Mordovskiy E.A., Solov’ev A.G., Sannikov A.L. Alkogol’nyy anamnez i faktor mesta nastupleniya smerti: rol’ v smertnosti ot vedushchikh zabolevaniy serdechno-sosudistoy sistemy [Alcohol Anamnesis and a Death Place Factor: Role in Mortality Rates Due to Leading Cardiovascular Diseases]. Terapevticheskiy arkhiv, 2015, no. 9, pp. 26–33. https://doi.org/10.17116/terarkh201587926-33
28. Solov’eva N.V., Bazhukova T.A., Solov’ev A.G. Mekhanizmy narusheniya funktsiy pecheni u bol’nykh s sindromom zavisimosti ot alkogolya [Mechanisms of Liver Dysfunction in Patients with Alcohol Dependence Syndrome]. Narkologiya, 2014, vol. 13, no. 12, pp. 31–34.
29. Gorshenina E.I., Sul’din A.M., Chugunova I.Yu., Shindakov V.G. Rol’ ω-3 polinenasyshchennykh zhirnykh kislot v profilaktike i lechenii serdechno-sosudistykh zabolevaniy [The Role of ω-3 Polyunsaturated Fatty Acids in Prevention and Treatment of Cardiovascular Diseases]. Zhurnal nauchnykh statey “Zdorov’e i obrazovanie v XXI v.”, 2019, vol. 21, no. 3, pp. 17–21.
30. Solovieva V.A., Leichter S.N., Solovieva N.V., Bichkaeva F.A., Ishekov N.S., Soloviev A.G. The Role of Saturated Fatty Acids in Impaired Lipid Metabolism in Patients with Alcohol Dependence Syndrome. Korsakov J. Neurol. Psychiatry, 2020, vol. 120, no. 9, pp. 93–97 (in Russ.). https://doi.org/10.17116/jnevro202012009193
31. Solovieva V.A., Leichter S.N., Solovieva N.V., Bichkayeva F.A., Ishekov N.S., Soloviev A.G., Medvedeva V.V. Content of Polyunsaturated Fatty Acids in Patients with Alcohol Dependence Syndrome. Narkologia, 2019, vol. 18, no. 8, pp. 53–59 (in Russ.).
32. Richard C., Calder P.C. Docosahexaenoic Acid. Adv. Nutr., 2016, vol. 7, no. 6, pp. 1139–1141. https://doi.org/10.3945/an.116.012963
33. Pristrom M.S., Shtonda M.V., Semenenkov I.I. Vzglyad na problemu stareniya: fokus na mesto omega-3 polinenasyshchennykh zhirnykh kislot v sisteme antistareniya [Point of View on the Problem of Aging: Focus on the Place of Omega-3 Polyunsaturated Fatty Acids in the Antiaging System]. Meditsinskie novosti, 2018, no. 9, pp. 45–53.
34. Carlson S.J., O’Loughlin A.A., Anez-Bustillos L., Baker M.A., Andrews N.A., Gunner G., Dao D.T., Pan A., Nandivada P., Chang M., Cowan E., Mitchell P.D., Gura K.M., Fagiolini M., Puder M. A Diet with Docosahexaenoic and Arachidonic Acids as the Sole Source of Polyunsaturated Fatty Acids Is Sufficient to Support Visual, Cognitive, Motor, and Social Development in Mice. Front. Neurosci., 2019, vol. 13. Art. no. 72. https://doi.org/10.3389/fnins.2019.00072