UDC

[612.13:612.592]-053.67

DOI

10.37482/2687-1491-Z237

Authors

Andrey B. Gudkov* ORCID: https://orcid.org/0000-0001-5923-0941
Elena V. Korobitsyna* ORCID: https://orcid.org/0000-0002-6622-2699
O’lga N. Popova* ORCID: https://orcid.org/0000-0002-0135-4594
Aleksandr N. Nikanov** ORCID: https://orcid.org/0000-0003-3335-4721
Sergey V. Kolmogorov*** ORCID: https://orcid.org/0000-0002-9339-500X
*Northern State Medical University
(Arkhangelsk, Russia)
**The Northwest Public Health Research Center
(St. Petersburg, Russia)
***Northern (Arctic) Federal University named after M.V. Lomonosov
(Arkhangelsk, Russia)

Abstract

Studying the effects of hypothermia on the human body is a pressing issue for modern physiology and practical medicine. The purpose of this article was to establish sex-related features of the haemodynamic response to local cold exposure of the hand in young people. Materials and methods. The research involved apparently healthy young men (n = 27) and women (n = 30) aged 18–20 years, born and permanently living in the Arctic zone of the Russian Federation. The stress test included immersion of the hand in 8 °C water for 1 min. It took 25 min to fully recover after cold exposure. The temperature of 24 °C served as the baseline. Haemodynamic parameters were recorded using SIMONA 111 Integrated Monitoring System (Russia). The following were determined: myocardial contractility indices, heart rate, pulsatility index (a marker of peripheral vascular resistance) as well as integral indicators reflecting the overall level of functional capabilities of the circulatory system. Results. Short-term cold exposure of the hand was found to cause a negative inotropic (decreased myocardial contractility) and a negative chronotropic (decreased heart rate) effects. At the same time, an increase in the body’s functional reserves was detected. The analysis of haemodynamic parameters showed differences in the response of the circulatory system between the examined groups of young men and women. The effect of local cooling of the hand on the cardiovascular system was more pronounced in women than in men. In addition, responses of different groups of haemodynamic parameters were identified: while in men changes occurred primarily due to lowered peripheral vascular resistance and increased blood pressure, in women they were caused by a decrease in contractility indices and myocardial parameters.

Keywords

local cooling, hand cooling, response of the cardiovascular system to cold, sex-related features of haemodynamics, thermal sensitivity, natives of the Russian Arctic

References

1. Gribanov A.V., Gudkov A.B., Popova O.N., Kraynova I.N. Krovoobrashchenie i dykhanie u shkol’nikov v tsirkumpolyarnykh usloviyakh [Blood Circulation and Breathing in Schoolchildren in Circumpolar Conditions]. Arkhangelsk, 2016. 270 p.
2. Boyko E.R. Metodicheskie podkhody k issledovaniyu vliyaniya faktorov Severa na organizm cheloveka [Method Approaches to Studying Effects of North Factors on Human Body]. Vestnik obrazovaniya i razvitiya nauki Rossiyskoy akademii estestvennykh nauk, 2020, no. 1, pp. 82–88. https://doi.org/10.26163/RAEN.2020.46.81.013
3. Mironovskaya A.V., Buzinov R.V., Gudkov A.B. Prognoznaya otsenka neotlozhnoy serdechno-sosudistoy patologii u naseleniya severnoy urbanizirovannoy territorii [Prognostic Evaluation of Urgent Cardiovascular Disease in the Population of a Northern Urbanized Area]. Zdravookhranenie Rossiyskoy Federatsii, 2011, no. 5, pp. 66–67.
4. Martin S.A., Hadmaș R.M. Individual Adaptation in Cross-Country Skiing Based on Tracking During Training Conditions. Sports (Basel), 2019, vol. 7, no. 9. Art. no. 211. https://doi.org/10.3390/sports7090211
5. Kozyreva T.V., Tkachenko E.Y., Potapova T.A., Voevoda M.I. Respiratory System Response to Local Cooling in Subjects with Single Nucleotide Polymorphism rs11562975 of the TRPM8 Temperature-Sensitive Ion Channel Gene. Hum. Physiol., 2014, vol. 40, no. 2, pp. 197–200. https://doi.org/10.1134/S0362119714020108
6. Kozyreva T.V. Central and Peripheral Thermoreceptors. Comparative Analysis of the Effects of Prolonged Adaptation to Cold and Noradrenaline. Neurosci. Behav. Physiol., 2007, vol. 37, no. 2, pp. 191–198. https://doi.org/10.1007/s11055-007-0167-4
7. Averyanova I.V. Cardiohemodynamic Response to Local Cold Exposure Among Men from Coastal and Inland Zones of the Magadan Region. Hum. Ecol., 2021, no. 10, pp. 29–36. https://doi.org/10.33396/1728-0869-2021-10-29-36
8. Baranova T.I., Rybyakova T.V., Dmitrieva M.O., Anisimov D.A., Tarasova M.S., Ogannisyan M.G. Specifics of Reaction of Human Cardiovascular System to Immersion in Cold Water. Extrem. Med., 2023, vol. 25, no. 4, pp. 98–106. https://doi.org/10.47183/mes.2023.053
9. Gudkov A.B., Popova O.N., Skripal’ B.A. Reaktsiya sistemy vneshnego dykhaniya na lokal’noe okhlazhdenie u molodykh lits trudosposobnogo vozrasta [External Respiration System Reaction to Local Cooling of Skin of Young Able-Bodied Persons]. Meditsina truda i promyshlennaya ekologiya, 2009, no. 4, pp. 26–30.
10. Popova O.N. Kharakteristika adaptivnykh reaktsiy vneshnego dykhaniya u molodykh lits trudosposobnogo vozrasta, zhiteley Evropeyskogo Severa [Characteristics of Adaptive Reactions of External Respiration in Young Working-Age People Living in the European North: Diss.]. Moscow, 2009. 278 p.
11. Gribanov A.V., Anikina N.Yu., Kozhevnikova I.S., Malyavskaya S.I., Pankov M.N. Cerebral Energy Metabolism Reaction to Cold Stress in Young People Living in the Arctic Region. Hum. Ecol., 2019, no. 3, pp. 17–23 (in Russ.). https://doi.org/10.33396/1728-0869-2019-3-17-23
12. Gerasimova-Meygal L.I., Tabaev I.A. Vazomotornye reaktsii na lokal’noe okhlazhdenie u molodykh lits s nikotinovoy zavisimost’yu [Vasomotor Reactions on Local Cooling in Young Individuals with Nicotine Addiction]. Krymskiy zhurnal eksperimental’noy i klinicheskoy meditsiny, 2020, vol. 10, no. 3, pp. 5–11. https://doi.org/10.37279/2224-6444-2020-10-3-5-11
13. Johnson J.M., Kellogg D.L. Jr. Skin Vasoconstriction as a Heat Conservation Thermoeffector. Handb. Clin. Neurol., 2018, vol. 156, pp. 175–192. https://doi.org/10.1016/B978-0-444-63912-7.00011-4
14. Orlov G.A. Khronicheskoe porazhenie kholodom [Chronic Cold Injury]. Moscow, 1978. 167 p.