UDC

[612.825+612.146.3](045)

Authors

Poskotinova Liliya Vladimirovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences; Institute of Medical and Biological Research, Northern (Arctic) Federal University named after M.V. Lomonosov (Arkhangelsk, Russia)

Stavinskaya Olga Aleksandrovna, The Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Balashova Svetlana Nikolaevna, Postgraduate Student, Institute of Environmental Physiology, Ural Branch of the Russian Academy of Sciences (Arkhangelsk, Russia)

Abstract

In apparently healthy people and those with initial signs of arterial hypertension who are not receiving antihypertensive therapy, low neuropeptide Y levels in serum (below 0.36 ng/ml) to a lesser extent depend on changes in central hemodynamics and are primarily associated with dysfunction in bioelectric brain activity due to impaired thalamo-cortical connections, increased activity of the midline brain structures and risk of photosensitive paroxysmal brain dysfunction.

Keywords

neuropeptide Y, electroencephalogram, arterial hypertension.

References

1. Baevskiy R.M., Ivanov G.G., Chireykin L.V. et al. Analiz variabel’nosti serdechnogo ritma pri ispol’zovanii razlichnykh elektrokardiograficheskikh sistem (metodicheskie rekomendatsii) [Analysis of heart rate variability using different electrocardiographic systems (guidelines)]. Vestnik aritmologii, 2001, no. 24, pp. 65–87.
2. Zhirmunskaya E.A., Losev V.S. Sistemy opisaniya i klassifikatsiya elektroentsefalogramm cheloveka [Systems of description and classification of human electroencephalograms]. Moscow, Nauka Publ., 1984.
3. Zenkov L.R., Ronkin M.A. Funktsional’naya diagnostika nervnykh bolezney (Rukovodstvo dlya vrachey) [Functional diagnosis of neurological diseases (Manual for physicians)]. Moscow, MEDpress-inform Publ., 2004.
4. Kobalava Zh.D., Kotovskaya Yu.V., Moiseev V.S. Arterial’naya gipertoniya. Klyuchi k diagnostike i lecheniyu [Hypertension. Keys to diagnosis and treatment]. Moscow, GEOTAR-Media Publ., 2009.
5. Latash L.P. Gipotalamus, prisposobitel’naya aktivnost’ i elektroentsefalogramma [Hypothalamus, adaptive activity and electroencephalogram]. Moscow, Nauka Publ., 1968. 295 p.
6. Nozdrachev A.D., Maslyukov P.M. Neyropeptid Y i avtonomnaya nervnaya sistema [Neyropeptid Y and the autonomic nervous system]. Zhurnal evolyutsionnoy fiziologii i biokhimii, 2011, vol. 47, no. 2, pp.105–112.
7. Natsional’nye rekomendatsii po diagnostike i lecheniyu arterial’noy gipertoniyu (Moskva) [National guidelines for the diagnosis and treatment of arterial hypertension (Moscow)], 2009. Available at: http://www.scardio.ru/recommendations/approved000DE/default.asp (accessed 5 September 2012).
8. Pal’tsev M.A., Kvetnoy I.M. Rukovodstvo po neyroimmunoendokrinologii [A guide to Neuroimmune Endocrinology]. Moscow, OAO “Izdatel’stvo Meditsina” Publ., 2008.
9. Popov V.V., Khasanova N.M., Sharashova E.E., Kudryavtsev A.V. Rasprostranennost’ i dinamika zabolevaemosti, smertnosti, letal’nosti pri ostrykh tserebrovaskulyarnykh zabolevaniyakh u zhiteley Arkhangel’ska [Prevalence and dynamics of morbidity, mortality, lethality in acute cerebrovascular diseases in Arkhangelsk residents]. Ekologiya cheloveka, 2011, no. 7, pp. 48–54.
10. Chesnokova V.N., Gribanov A.V. Izmenenie gemodinamiki u studentov v usloviyakh severnogo regiona v techenie uchebnogo goda [Changing in cerebral hemodynamics of the adolescents in the conditions of life in the northern region during the academic year]. Sovremennye problemy nauki i obrazovaniya, 2012, no. 1, pp. 5–12.
11. Van Raay L., Jovanovska V., Morris M.J., O’Brien T.J. Focal administration of neuropeptide Y into the S2 somatosensory cortex maximally suppresses absence seizures in a genetic rat model. Epilepsia, 2012, vol. 53 (3), pp. 477–484.
12. Held K., Antonijevic I., Murck H., et al. Neuropeptide Y (NPY) shortens sleep latency but does not suppress ACTH and cortisol in depressed patients and normal controls. Psychoneuroendocrinology, 2006, vol. 31 (1), pp. 100–107.
13. Hodges G. J., Jackson D. N., Mattar L., et al. Neuropeptide Y and neurovascular control in skeletal muscle and skin. American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, 2009, vol. 297, pp. 546–555.
14. Noè F., Pool A.H., Nissinen J., et al. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain, 2008, vol. 131, pp.1506–1515.
15. Stroud L.M., O’Brien T.J., Jupp B., et al. Neuropeptide Y suppresses absence seizures in a genetic rat model. Brain Research, 2005, vol. 1033 (2), pp. 151–156.
16. Toth A., Zaborszky L., Detari L. EEG effect of basal forebrain neuropeptide Y administration in urethane anaesthetized rats. Brain Research Bulletin, 2005, vol. 66 (1), pp. 37–42.