UDC

612.118.221.2.

Authors

Tsirkin Viktor Ivanovich, General Medicine Faculty, Kazan State Medical University (Kazan, Russia)

Volodchenko Anna Ivanovna, Postgraduate Student, Natural Geography Faculty, Vyatka State Humanities University (Kirov, Russia)

Kostyaev Andrey Aleksandrovich, Kirov Research Institute of Hematology and Blood Transfusion (Kirov, Russia)

Abstract

Acetylcholine (ACh, 10-10–10-6 g/ml) dose-dependently increases the rate of erythrocyte agglutination in men. This effect is reduced by selective blockers of M1- and M3-cholinergic receptors (ChR):gastrotsepin and 4-DAMP, inhibitor of cyclooxygenase and phospholipase A2 indomethacin, inhibitor of calmodulin trifluoperazine, blocker of Ca2+-dependent K+-channels BaCl2, and blocker of Ca2+-channels verapamil. This means that the effect of ACh is caused by the activation of M1- and M3-ChR and involves cyclooxygenase, phospholipase A2, calmodulin and Ca2+- and К+-channels.

Keywords

erythrocytes, agglutination, acetylcholine, muscarinic receptors, cyclooxygenase, phospholipase A2, calmodulin.

References

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