UDC

53.083.32:612.741:616-056.3:616.74-02-092.9

Authors

Smirnova Natalya Nikolaevna, Faculty of Clinical Psychology and Social Work, Northern State Medical University (Arkhangelsk, Russia)

Solovyev Andrey Gorgonyevich, Department of Psychiatry and Clinical Psychology, Northern State Medical University (Arkhangelsk, Russia)

Abstract

The participation of ATP in plasticity mechanisms of striated muscles at protein sensitization (PS) in mice was investigated. Contractile function and non-quantum acetylcholine secretion in the endplate zone (H-effect) was studied in lower leg isolated skeletal muscles m.soleus and m.extensor digitorum longus (m.EDL) and strips of m.diaphragma. The data indicate that ATP participates in mechanisms of functional changes in m.soleus and m.diaphragma at PS and helps develop mechanisms of resistance to external loads in these muscles.

Keywords

muscle contractility, non-quantum acetylcholine secretion, m. diaphragm, m.soleus, m.extensor digitorum longus, mouse, protein sensitization, ATР.

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